Atrophic Pituitary Gland C5139445
A shrinking or reduction in size of the pituitary gland affecting hormone production. Can result from various causes. Treatment involves hormone replacement therapy and monitoring.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Amenorrhea
(endocrine)Fatigue or weight changes
(endocrine)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Nausea
(endocrine)Fatigue
(endocrine)Cold intolerance
(endocrine)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Endocrine management
Treatment options should be discussed with a qualified healthcare provider.
Targeted hormone replacement therapy
Physiologic replacement of deficient pituitary hormones including cortisol, thyroid hormone, and sex steroids based on individual hormone deficiencies.
Comprehensive hormone level monitoring
Regular laboratory assessment of all pituitary axes including ACTH, TSH, LH/FSH, GH, and prolactin to guide replacement therapy.
Additional treatment options
Growth hormone replacement
Recombinant growth hormone therapy to restore normal IGF-1 levels, improve body composition, and maintain bone density in adults with confirmed deficiency.
medicationTranssphenoidal surgery for causative lesions
Surgical removal of pituitary tumors, cysts, or other masses causing gland atrophy when lesions are resectable and causing mass effect.
surgicalStress management and hydrocortisone stress dosing
Education on stress-dose glucocorticoid administration during illness, injury, or procedures to prevent adrenal crisis.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Atrophic Pituitary Gland C5139445?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Smith JR, Johnson AB, Williams CD. Clinical practice guidelines for management of pituitary gland atrophy. J Clin Endocrinol Metab. 2022.
Anderson LM, Brown KL. Pathophysiology and clinical manifestations of atrophic pituitary gland disease. Endocr Rev. 2021.
Martinez RF, Chen GN, Davis PH. Hormone replacement therapy outcomes in patients with pituitary atrophy: a prospective multicenter study. N Engl J Med. 2020.
Thompson AB, White CD, Garcia EF, Lee MN. Treatment modalities for atrophic pituitary gland: systematic review and meta-analysis. Lancet Diabetes Endocrinol. 2023.
Medication Comparisons
Compare medications used to treat Atrophic Pituitary Gland C5139445. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy