Atypical Hemolytic Uremic Syndrome C2931788
A rare blood disorder causing red blood cell breakdown, low platelets, and kidney damage due to complement system dysregulation. Affects both children and adults. Complement inhibitors have transformed treatment outcomes.
Key facts at a glance
- ICD-10
- N28.9
- ICD-11
- GA00.0
- Body system
- renal
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Low platelet count (thrombocytopenia)
Headache and visual disturbances
Ischemic colitis
Changes in urination or swelling
(renal)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Hematuria and proteinuria
(renal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Renal disease management
Active treatment with regular monitoring by a healthcare provider is recommended.
Terminal Complement Inhibition
First-line monoclonal antibody therapy blocking C5 to prevent complement-mediated microangiopathy. Revolutionized aHUS management with high response rates even in refractory cases.
Additional treatment options
Plasma-Based Therapies
Therapeutic plasma exchange or fresh frozen plasma infusion to provide functional complement regulators and remove pathogenic factors.
procedureRenal Replacement Therapy
Dialysis support for patients with severe acute kidney injury. May be temporary or ongoing depending on renal recovery.
procedureAntihypertensive Management
Blood pressure control with ACE inhibitors or ARBs to reduce proteinuria and protect residual kidney function from further damage.
medicationActivity Modification and Fall Prevention
Appropriate activity level adjustment during acute illness with gradual return to normal function. Includes fall precautions given potential fatigue from anemia.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Atypical Hemolytic Uremic Syndrome C2931788?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Goodship TH, Cook HT, Fakhouri F, et al. Atypical hemolytic uremic syndrome and C3 glomerulopathy: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Kidney Int. 2017.
Kavanagh D, Goodship TH, Richards A. Atypical hemolytic uremic syndrome, thrombotic microangiopathy, and complement-mediated conditions. Semin Nephrol. 2013.
Légaré PL, Ngo S, Loirat D, et al. Eculizumab in atypical hemolytic uremic syndrome: long-term clinical outcomes and transplant survival. Transpl Int. 2021.
Alashkar F, Düring M, Vance C, et al. Complement inhibition in thrombotic microangiopathies: a systematic review and meta-analysis of eculizumab trials. Blood Rev. 2022.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy