Atypical Hemolytic Uremic Syndrome With C3 Anomaly C2752037
A rare aHUS variant involving genetic mutations affecting complement protein C3. Often presents in childhood. Treatment with complement inhibitors has significantly improved outcomes.
Key facts at a glance
- ICD-10
- Q63.9
- ICD-11
- LA00.0
- Body system
- renal
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Microangiopathic hemolytic anemia
Thrombocytopenia
Severe hypertension
Seizures
Changes in urination or swelling
(renal)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Complement C5 inhibitor therapy
Targeted inhibition of terminal complement pathway to prevent uncontrolled activation and endothelial injury associated with C3 dysregulation.
Renal disease management
Active treatment with regular monitoring by a healthcare provider is recommended.
Plasma infusion therapy
Direct infusion of fresh frozen plasma to supplement deficient or dysfunctional complement components, particularly C3, restoring normal regulatory function.
Additional treatment options
Kidney transplantation with complement coverage
Definitive treatment for end-stage renal disease with living donor transplant, performed under complement inhibition coverage to prevent recurrent disease in graft.
surgicalCorticosteroid therapy
Immunosuppressive agents to reduce inflammatory components and complement activation in acute flares or when other therapies are contraindicated.
medicationComplement pathway monitoring
Serial measurement of complement C3 and C4 levels, CH50, and genetic analysis to guide treatment duration and detect early recurrence.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Atypical Hemolytic Uremic Syndrome With C3 Anomaly C2752037?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Goodship TH, Cook HT, Fakhouri F, et al. Atypical hemolytic uremic syndrome and C3 glomerulopathy: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Kidney Int. 2017.
Fakhouri F, Zuber J, Frémeaux-Bacchi V, Loirat C. Haemolytic uraemic syndrome. Lancet. 2017.
Legendre CM, Licht C, Muus P, et al. Terminal complement inhibitor eculizumab in atypical hemolytic-uremic syndrome. N Engl J Med. 2013.
Nester CM, Barbour T, de Jorge EG, et al. Atypical aHUS: State of the art. Mol Immunol. 2015.
Medication Comparisons
Compare medications used to treat Atypical Hemolytic Uremic Syndrome With C3 Anomaly C2752037. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy