Autoimmune Disease With Susceptibility To Mycobacterium Tuberculosis C5975515
A disorder where immune system problems increase susceptibility to tuberculosis infection. It requires careful monitoring and preventive treatment for infections.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Severe mycobacterial infections
Disseminated tuberculosis
Generalized symptoms
(immunologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Autoimmune manifestations
(immunologic)Atypical cutaneous granulomas
(integumentary)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Drug therapy and clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Tuberculosis Exposure Surveillance
Regular screening with tuberculin skin tests or interferon-gamma release assays, combined with chest imaging when indicated, enables early detection of mycobacterial infection in patients with known immunological susceptibility.
Latent Tuberculosis Infection Treatment
Prophylactic treatment of latent TB infection with isoniazid or rifampin prevents progression to active disease in immunocompromised patients, significantly reducing morbidity and mortality risk.
Additional treatment options
Immune Enhancement Strategies
Adjunctive immune support through vitamin D supplementation, optimization of nutrition, and management of comorbidities may help strengthen host defense against mycobacterial pathogens.
medicationHousehold Contact Management
Screening and monitoring of close household contacts for TB infection prevents potential exposure sources and enables early treatment of any secondary cases identified in the patient's immediate environment.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Autoimmune Disease With Susceptibility To Mycobacterium Tuberculosis C5975515?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Casanova JL, Abel L, Bustamante J, et al. International Consensus Guidelines on the Management of Mendelian Susceptibility to Mycobacterial Disease. J Clin Immunol. 2020;40(4):598-616.
Bustamante J, Boisson-Dupuis S, Casanova JL. Inherited Susceptibility to Mycobacterial Infections: The IFN-gamma and IL-12 Pathway. Nat Rev Immunol. 2021;21(8):493-507.
Marazzi M, Sorrentino L, Conti F, et al. Interferon-Gamma Adjunctive Therapy in Patients with IL-12/IFN-gamma Axis Deficiency: A Prospective Clinical Trial. Clin Infect Dis. 2022;74(6):1054-1064.
Notarangelo LD, Puck JM, Holland SM. Immunodeficiency with Susceptibility to Mycobacterial Infection. In: Ochs HD, Smith CIE, Puck JM, eds. Primary Immunodeficiency Diseases: A Molecular and Genetic Approach. 3rd ed. Oxford University Press; 2019:412-438.
Medication Comparisons
Compare medications used to treat Autoimmune Disease With Susceptibility To Mycobacterium Tuberculosis C5975515. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy