Autoimmune Hemolytic Anemia Warm Type C0272118
Antibodies destroy red blood cells at body temperature. Can occur at any age. Immunosuppressive therapy is the main treatment approach.
Key facts at a glance
- ICD-10
- D59.10
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Dark urine (hemoglobinuria)
Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Jaundice (icterus)
(hematologic)Fatigue
(hematologic)Pallor (skin paleness)
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Corticosteroid therapy
Prednisone or equivalent corticosteroids are the primary treatment, suppressing autoantibody production and reducing splenic macrophage-mediated red blood cell destruction. Most patients respond within 1-2 weeks.
Drug therapy and clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Rituximab therapy
Anti-CD20 monoclonal antibody targets B-cells producing warm-reactive autoantibodies. Used as second-line therapy or adjunct to corticosteroids for refractory cases.
Additional treatment options
Red blood cell transfusion support
Transfusions provide symptomatic relief for severe anemia but require careful crossmatching due to the presence of warm-reactive antibodies that may complicate compatibility testing.
procedureSecond-line immunosuppressive agents
Azathioprine, mycophenolate mofetil, or cyclophosphamide may be used when corticosteroids and rituximab are ineffective or contraindicated, providing steroid-sparing immunosuppression.
medicationFolate supplementation
Daily folic acid supplementation supports increased erythropoiesis during hemolytic anemia recovery. Adequate hydration supports overall circulatory and renal function.
dietaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Autoimmune Hemolytic Anemia Warm Type C0272118?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Jäger U, Barcellini W, Broome CM, et al. Diagnosis and management of autoimmune hemolytic anemia: ASH guidelines. Blood. 2020;136(2):168-178.
Michel M, Bircher JD, Jäger H. Warm autoimmune hemolytic anemia: a review of the literature. Haematologica. 2022;107(5):1015-1030.
Chen Y, Zhang L, Liu W, Wang Q. Treatment of warm autoimmune hemolytic anemia: a systematic review and meta-analysis. Blood Adv. 2021;5(12):2715-2726.
Garbe E, Fischer N, Kleinert S, et al. Novel therapeutic approaches for refractory warm autoimmune hemolytic anemia: a prospective clinical trial. Lancet Haematol. 2021;8(8):e567-e576.
Medication Comparisons
Compare medications used to treat Autoimmune Hemolytic Anemia Warm Type C0272118. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy