Autoimmune Urticaria C1304191
A chronic skin condition causing hives due to autoimmune reactions that trigger histamine release. Can affect anyone and often persists long-term. Usually managed with antihistamines and sometimes immunosuppressants.
Key facts at a glance
- ICD-10
- L98.9
- ICD-11
- EA00.0
- Body system
- dermatologic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(dermatologic)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Second-generation antihistamines
Oral antihistamines such as cetirizine, loratadine, or fexofenadine as first-line therapy to block histamine release and reduce hive formation and itching.
Omalizumab injection
Monoclonal antibody therapy targeting IgE for patients with inadequate response to antihistamines. Administered as subcutaneous injections every 4 weeks.
Additional treatment options
Trigger avoidance and skin care
Identification and avoidance of personal triggers including certain foods, medications, temperature changes, and stress. Implementation of gentle skin care routines.
lifestyleNarrowband UVB phototherapy
Controlled ultraviolet light exposure to reduce immune-mediated skin inflammation and mast cell activity in chronic cases.
procedureImmunosuppressive agents
Cyclosporine or other immunosuppressants for severe, refractory autoimmune urticaria when other treatments fail.
medicationWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Autoimmune Urticaria C1304191?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Zuberbier T, Abdul Latiff AH, Abuzakouk M, et al. The EAACI/GA²LEN/EDF/WAO guideline for the definition, classification, diagnosis, and management of urticaria. Allergy. 2022;77(9):2603-2621.
Kaplan AP, Greaves M, Saini SS. Autoimmune Urticaria: Pathophysiology and Clinical Management. Immunol Allergy Clin North Am. 2021;41(2):253-269.
Maurer M, Rosén K, Hsieh HJ, et al. Omalizumab for the treatment of chronic spontaneous urticaria: A systematic review and meta-analysis. J Allergy Clin Immunol Pract. 2020;8(8):2558-2570.e5.
Sánchez-Borges M, Asero R, Ansotegui IJ, et al. Diagnosis and treatment of urticaria and angioedema: A worldwide perspective. World Allergy Organ J. 2018;1(9):271-285.
Medication Comparisons
Compare medications used to treat Autoimmune Urticaria C1304191. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy