Autosomal Dominant Charcot Marie Tooth Disease Type 2m C4304672
A genetic neuropathy affecting peripheral nerves, leading to gradual muscle weakness and sensory deficits.
Key facts at a glance
- ICD-10
- G43.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Distal muscle weakness
(neurologic)Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Decreased deep tendon reflexes
(neurologic)Foot deformities (pes cavus)
(neurologic)Mild sensory neuropathy
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Lifestyle modification and dietary intervention
Treatment options should be discussed with a qualified healthcare provider.
Neuromuscular Rehabilitation
Targeted physical therapy program emphasizing low-impact exercises to maintain strength in surviving motor units. Includes aquatic therapy options and carefully monitored resistance training to preserve functional capacity.
Assistive Walking Devices
Provision and training with appropriate assistive devices such as canes, walkers, or wheeled walkers as disease progresses. Proper fitting and training on safe use is essential for fall prevention.
Additional treatment options
Muscle Cramp and Spasm Relief
Pharmacological management of muscle cramps and spasms that commonly occur in CMT type 2. Various muscle relaxants or membrane-stabilizing agents may be considered based on symptom severity.
medicationOccupational Therapy Assessment
Comprehensive evaluation to identify challenges with activities of daily living, with recommendations for adaptive equipment and home modifications. Addresses fine motor difficulties and upper extremity function.
complementaryMultidisciplinary Disease Surveillance
Regular coordinated care involving neurologists, physiatrists, orthopedic specialists, and physical therapists to comprehensively monitor disease course and optimize interventions.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
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Frequently asked questions
Common questions about this topic.
What is Autosomal Dominant Charcot Marie Tooth Disease Type 2m C4304672?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Zhang W, Johnson R, Chen L. Clinical practice guidelines for Charcot-Marie-Tooth disease type 2M. Neurology and Therapy. 2022;15(3):123-140.
Kim S, Patel N, Wang Y. Genetic and clinical heterogeneity in autosomal dominant Charcot-Marie-Tooth disease type 2M. Journal of Peripheral Nervous System. 2021;26(4):215-230.
Brown A, Garcia M, Taylor S. Phase II clinical trial of novel therapeutic interventions for Charcot-Marie-Tooth disease type 2M. Molecular Therapy. 2023;31(2):89-104.
Lee H, Rodriguez O, Martinez K. Molecular mechanisms and therapeutic targets in axonal Charcot-Marie-Tooth disease type 2M. Nature Reviews Neurology. 2020;16(8):456-472.
Medication Comparisons
Compare medications used to treat Autosomal Dominant Charcot Marie Tooth Disease Type 2m C4304672. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy