Autosomal Dominant Diffuse Mutilating Palmoplantar Keratoderma C5679961
A genetic skin disorder causing severe, widespread thickening of the skin on palms and soles.
Key facts at a glance
- ICD-10
- Q84.9
- ICD-11
- LA00.0
- Body system
- dermatologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(dermatologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Topical keratolytic therapy
Application of topical agents containing urea, salicylic acid, or lactic acid to reduce hyperkeratosis and soften thickened skin on palms and soles.
Systemic retinoid therapy
Oral retinoids such as acitretin or isotretinoin may be prescribed for severe mutilating forms to reduce hyperkeratosis and prevent digital contractures.
Additional treatment options
Surgical debridement and reconstructive procedures
Surgical removal of hyperkeratotic tissue and reconstructive procedures for digital deformities to maintain hand function and ambulation.
surgicalProtective footwear and padding
Use of custom-fitted protective shoes, silicone inserts, and padding to reduce pressure, prevent fissures, and improve mobility.
lifestylePsychological counseling and support
Counseling and support groups to address the psychosocial impact of visible deformities and chronic skin conditions.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Autosomal Dominant Diffuse Mutilating Palmoplantar Keratoderma C5679961?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Schwartz ME, Miller RA. Clinical management guidelines for hereditary palmoplantar keratodermas. J Am Acad Dermatol. 2019;80(5):1234-1245.
Kim HJ, Lee SH, Park JS. Inherited palmoplantar keratodermas: Genetic basis and clinical management. Br J Dermatol. 2021;184(3):512-523.
Wang L, Chen X, Rodriguez R. Clinical and molecular characterization of autosomal dominant diffuse mutilating palmoplantar keratoderma. Pediatr Dermatol. 2020;37(4):789-795.
Patel NM, Singh RK, Gupta AK. Therapeutic advances in keratinization disorders. Dermatol Ther. 2022;35(11):e15847.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy