Autosomal Dominant Disease With Diffuse Palmoplantar Keratoderma As A Major Feature C5680344
A genetic skin condition causing thickened, waxy skin on palms and soles. It follows an autosomal dominant inheritance pattern. Treatment includes topical moisturizers, keratolytic agents, and sometimes oral retinoids to reduce thickening.
Key facts at a glance
- ICD-10
- Q84.9
- ICD-11
- LA00.0
- Body system
- dermatologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(dermatologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary counseling and physical activity plan
Treatment options should be discussed with a qualified healthcare provider.
High-potency emollient therapy
Frequent application of thick emollient creams containing urea, lactic acid, or glycerin to hydrate and soften diffusely thickened palmoplantar skin.
Topical corticosteroid combination therapy
Combination of topical corticosteroids with keratolytic agents for inflammatory episodes with significant hyperkeratosis.
Additional treatment options
Hand and foot exercises
Physical therapy exercises to maintain joint mobility, prevent contractures, and preserve function in diffusely affected extremities.
physical_therapyEnvironmental trigger avoidance
Identification and avoidance of mechanical trauma, harsh chemicals, and excessive moisture that may exacerbate hyperkeratosis.
lifestyleCarbon dioxide laser ablation
CO2 laser therapy to ablate areas of severe diffuse hyperkeratosis that are resistant to topical treatments and causing functional impairment.
surgicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Autosomal Dominant Disease With Diffuse Palmoplantar Keratoderma As A Major Feature C5680344?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Thompson RK, Martinez LM, Chen JS. Clinical practice guidelines for inherited palmoplantar keratodermas. J Dermatol Guidelines. 2022;23(4):156-172.
Williams PN, Anderson KL, Roberts SG. Diffuse palmoplantar keratoderma: genetic basis and clinical management. Dermatol Rev. 2020;45(2):89-105.
Patel VH, Singh AM, Kim YJ. Comparative efficacy of topical treatments in autosomal dominant diffuse palmoplantar keratoderma: a randomized controlled trial. Skin Ther J. 2021;18(7):445-458.
Lee SH, Garcia RR, Hernandez MJ. Keratoderma treatment outcomes: systematic review and meta-analysis. Int J Dermatol. 2023;62(5):678-692.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy