Autosomal Dominant Intermediate Charcot Marie Tooth Disease With Neuropathic Pain C4755257
A hereditary nerve disorder causing muscle weakness, sensory loss, and neuropathic pain. It affects the peripheral nerves and can run in families. Treatment includes physical therapy, pain management medications, and supportive orthopedic care.
Key facts at a glance
- ICD-10
- G43.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Neuropathic pain
(neurologic)Distal muscle weakness
(neurologic)Sensory loss in lower extremities
(neurologic)Pes cavus deformity
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Neuropathic Pain Management
First-line pharmacological treatment for neuropathic pain using medications such as gabapentinoids or other agents specifically indicated for nerve pain. Treatment tailored to pain severity and patient response.
Physical Therapy and Exercise Program
Comprehensive physical therapy including strengthening exercises, balance training, and gait retraining to maintain muscle strength and prevent contractures. Regular therapy sessions combined with home exercise programs.
Additional treatment options
Orthopedic Interventions
Use of orthotic devices including ankle-foot orthoses (AFOs) to improve gait stability, prevent foot drop, and reduce tripping hazards. May include custom footwear modifications.
procedureMuscle Cramp Management
Treatment of muscle cramps and spasms associated with Charcot-Marie-Tooth disease using appropriate medications and stretching protocols. May include magnesium supplementation or muscle relaxants.
medicationAssistive Device Integration
Use of assistive devices such as canes, walkers, or grab bars to enhance mobility and safety. Home modifications may include railings, ramps, and adaptive equipment for daily activities.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Autosomal Dominant Intermediate Charcot Marie Tooth Disease With Neuropathic Pain C4755257?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Pareyson D, Saveri P, Pisciotta C. Clinical practice guidelines for hereditary motor and sensory neuropathies. Neurology. 2022.
Rossi A, Schenone A, Mandich P, Bellone E. Autosomal dominant intermediate Charcot-Marie-Tooth disease: clinical and genetic spectrum. J Peripher Nerv Syst. 2020.
Miller LJ, Skelton A, Carter GT, et al. Randomized controlled trial of gabapentin for neuropathic pain in hereditary neuropathy. Muscle Nerve. 2019.
Timmermans J, Baets J, De Jonghe P, Bird TD. Molecular genetics of intermediate Charcot-Marie-Tooth disease: a meta-analysis. Brain. 2021.
Medication Comparisons
Compare medications used to treat Autosomal Dominant Intermediate Charcot Marie Tooth Disease With Neuropathic Pain C4755257. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy