Autosomal Dominant Parkinson Disease 8 C1846862
A genetic form of Parkinson's disease caused by mutations in the SNCA gene. Inherited in autosomal dominant pattern. Symptoms and treatment approach are similar to other forms of Parkinson's.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Bradykinesia
(neurologic)Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Resting tremor
(neurologic)Rigidity
(neurologic)Cognitive impairment
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
MAO-B inhibitors
Monoamine oxidase B inhibitors to reduce dopamine breakdown, used as initial therapy or adjunct to levodopa. May provide neuroprotective benefits in addition to symptomatic relief.
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Parkinson-specific exercise regimen
Comprehensive exercise program including aerobic training, strength work, and balance activities tailored to Parkinson symptoms. Regular participation essential for maintaining function.
Additional treatment options
Sleep hygiene optimization
Behavioral interventions and environmental modifications to improve sleep quality, address REM sleep behavior disorder, and manage nighttime symptoms common in Parkinson disease.
lifestyleMusic and dance therapy
Rhythm-based movement programs including dance therapy to improve gait, balance, and motor timing. Provides both physical and psychosocial benefits through engaging activities.
complementarySpeech and swallowing therapy
LSVT LOUD and other speech therapy approaches to address hypophonia, dysarthria, and swallowing difficulties. Essential for maintaining communication and safe eating.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Autosomal Dominant Parkinson Disease 8 C1846862?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Vance JM, Pericak-Vance MA. Genetics of Parkinson disease: LRRK2 and beyond. Neurogenetics. 2022.
International Parkinson and Movement Disorder Society. Genetic Testing in Parkinsonism: Recommendations. Mov Disord. 2021.
Schapira AHV, Hauser RA, Jankovic J. LRRK2 Inhibitor Trial in Parkinson Disease: Phase 2 Results. Lancet Neurol. 2023.
Klein CL, Lohmann K, Bruggemann N. Phenotypic Spectrum of LRRK2-Associated Parkinsonism: A Systematic Review. Ann Neurol. 2020.
Medication Comparisons
Compare medications used to treat Autosomal Dominant Parkinson Disease 8 C1846862. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy