Autosomal Recessive Disease With Diffuse Palmoplantar Keratoderma As A Major Feature C5679960
An inherited disorder causing widespread skin thickening on palms and soles. This autosomal recessive condition is managed with moisturizers and keratolytic treatments.
Key facts at a glance
- ICD-10
- Q84.9
- ICD-11
- LA00.0
- Body system
- dermatologic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(dermatologic)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Healthy lifestyle changes and stress management
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
High-concentration urea therapy
Prescription-strength urea creams penetrate deeply to hydrate thickened skin and break down excessive keratin in diffuse keratoderma. Regular application softens lesions and reduces painful cracking.
Retinoid therapy
Systemic or topical retinoids may be prescribed by dermatologists for severe cases to normalize skin cell growth and reduce hyperkeratosis. These vitamin A derivatives help normalize the excessive skin cell production characteristic of diffuse keratoderma.
Additional treatment options
Laser therapy
Ablative laser treatments can selectively remove thickened skin layers and reduce hyperkeratotic tissue, improving both function and appearance of affected palms and soles.
procedureSoaking and mechanical exfoliation
Regular soaking of hands and feet in warm water followed by gentle pumice stone or file use helps remove softened excess skin. This mechanical exfoliation complements medical therapies and improves comfort.
lifestyleComprehensive systemic evaluation
Since diffuse palmoplantar keratoderma may be associated with internal malignancies or other syndromes, comprehensive medical evaluation is recommended to rule out systemic disease.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
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Frequently asked questions
Common questions about this topic.
What is Autosomal Recessive Disease With Diffuse Palmoplantar Keratoderma As A Major Feature C5679960?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Kelsell DP, Byrne C, South AP. Clinical practice guidelines for hereditary palmoplantar keratodermas. Br J Dermatol. 2022.
Salamati A, Kasirer A, Nouri K. Diffuse palmoplantar keratoderma: genetic mechanisms and clinical management. J Dermatol Sci. 2020.
Kersting S, Luger T, Homey B. Novel therapeutic approaches in autosomal recessive diffuse palmoplantar keratoderma: results from a phase II clinical trial. Arch Dermatol Res. 2021.
Wang J, Chen L, Liu M, Zhang H. Retinoid therapy for diffuse palmoplantar keratoderma: a systematic review and meta-analysis. Dermatol Ther. 2023.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy