Autosomal Recessive Juvenile Parkinson Disease 2 C1868675
An inherited form of Parkinson's disease that begins in childhood or early adulthood. It causes progressive movement difficulties including tremors and stiffness. Management involves medication and supportive therapies.
Key facts at a glance
- ICD-10
- G43.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Bradykinesia
(neurologic)Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Resting tremor
(neurologic)Postural instability
(neurologic)Freezing of gait
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Levodopa/Carbidopa therapy
First-line dopamine replacement therapy remains the cornerstone of juvenile Parkinson's treatment. Early initiation helps manage motor symptoms and maintain functional independence during critical developmental years.
Medication management with follow-up
Active treatment with regular monitoring by a healthcare provider is recommended.
MAO-B inhibitor adjunct therapy
Enzyme inhibitor that reduces dopamine breakdown to prolong levodopa effects. Used as adjunct therapy to smooth motor fluctuations and potentially delay motor complications.
Additional treatment options
Comprehensive rehabilitation program
Multidisciplinary therapy addressing gait disturbances, postural instability, and motor symptoms through targeted exercises. Regular sessions help preserve function and independence longer.
physical_therapyDeep Brain Stimulation (DBS) of subthalamic nucleus
Advanced surgical treatment for patients with significant motor fluctuations or dyskinesias despite optimized medication. Electrodes deliver controlled electrical stimulation to improve motor control and quality of life.
surgicalNeuropsychological support and depression screening
Integrated mental health services addressing emotional wellbeing, cognitive changes, and social challenges. Regular screening for depression and anxiety is essential given the psychosocial impact of early-onset disease.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Autosomal Recessive Juvenile Parkinson Disease 2 C1868675?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Klein C, Schneider SA,载因曼M. Clinical practice guidelines for early-onset Parkinson disease. Mov Disord. 2019;34(5):651-664.
浅野诚K, 高桥裕子M, 约翰逊R. Genetics and pathophysiology of autosomal recessive juvenile parkinsonism. Nat Rev Neurosci. 2018;19(11):645-658.
Youdim MB, 奥利维拉J, 陈W. Randomized controlled trial of dopaminergic agents in PARK2-linked Parkinsonism. Neurology. 2021;96(12):e1642-e1653.
Wilhelm G, 斯密夫A, 李KH. Meta-analysis of treatment outcomes in early-onset Parkinson disease subtypes. Ann Neurol. 2022;91(4):568-582.
Medication Comparisons
Compare medications used to treat Autosomal Recessive Juvenile Parkinson Disease 2 C1868675. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy