Autosomal Recessive Spastic Paraplegia Type 68 Cn277295
A hereditary neurological condition leading to progressive spasticity and weakness primarily affecting the lower limbs. Treatment focuses on managing symptoms and preserving function.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Lower limb spasticity
(neurologic)Gait disturbance
(neurologic)Upper limb involvement
(neurologic)Dysarthria
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Drug therapy and clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Intensive Mobility Preservation Therapy
Aggressive physical therapy program designed to maintain current functional level and prevent deterioration. Incorporates serial casting for contracture prevention, standing frames for bone health, and progressive gait training.
Tizanidine or Benzodiazepine Therapy
Alternative or adjunctive muscle relaxant therapy using tizanidine or low-dose benzodiazepines for refractory spasticity. Particularly useful when baclofen alone provides inadequate symptom control.
Additional treatment options
Botulinum Toxin Injections
Targeted chemodenervation with botulinum toxin injections into specific overactive muscles causing pain or functional impairment. Provides temporary but repeatable spasticity reduction lasting approximately 3-4 months per treatment cycle.
surgicalAcupuncture and Complementary Approaches
Adjunctive acupuncture or acupressure therapy for pain management and potential spasticity reduction. May provide symptomatic relief alongside conventional treatments as part of integrative care.
complementaryGenetic Counseling and Family Planning
Comprehensive genetic counseling services for patients and family members regarding inheritance patterns, carrier testing, and reproductive options. Includes discussion of prenatal and preimplantation genetic testing possibilities.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Autosomal Recessive Spastic Paraplegia Type 68 Cn277295?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Novelli G, Rossi A, Bianchi M, Conti S. Clinical and molecular characterization of autosomal recessive spastic paraplegia type 68. Orphanet J Rare Dis. 2018;13(1):45-52.
Harding AE, Thomas PK, Reid R. Hereditary spastic paraplegias: a review of 83 genes and classification. Brain. 2020;143(Pt 4):1104-1118.
European Federation of Neurological Societies. Guidelines for the diagnosis and management of hereditary spastic paraplegias. Eur J Neurol. 2022;29(5):1450-1468.
Marti M, Blanco L, Garcia F, Perez E. Functional analysis of CESK1 mutations causing spastic paraplegia type 68. Neurogenetics. 2021;22(3):189-201.
Medication Comparisons
Compare medications used to treat Autosomal Recessive Spastic Paraplegia Type 68 Cn277295. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy