Autosomal Recessive Spastic Paraplegia Type 69 C5190577
A rare autosomal recessive disorder characterized by progressive spastic paraplegia. Management involves physical therapy and supportive measures to help maintain quality of life.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Spastic paraplegia
(neurologic)Lower limb spasticity
(neurologic)Gait disturbance
(neurologic)Peripheral neuropathy
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Intensive Spasticity Management Program
A comprehensive physical therapy program focusing on stretching, strength training, and gait retraining to manage spasticity and maintain mobility.
Medication management with follow-up
Active treatment with regular monitoring by a healthcare provider is recommended.
Antispasticity Medications
Systemic muscle relaxant medications such as baclofen or tizanidine to reduce muscle stiffness and improve function.
Additional treatment options
Intrathecal Baclofen Pump Implantation
Surgical placement of a drug delivery system directly into the cerebrospinal fluid for targeted spasticity control when oral medications are insufficient.
procedureMobility Assistive Devices
Use of appropriate assistive devices including braces, walkers, or wheelchairs to support independence and prevent falls.
lifestyleMultidisciplinary Neurological Monitoring
Regular follow-up with neurologists, physiatrists, and therapists to monitor disease progression and adjust treatment plans.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Autosomal Recessive Spastic Paraplegia Type 69 C5190577?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Shoukier M, Hegde S, Li Y. Recommended guidelines for diagnosis and management of hereditary spastic paraplegias. Neurology Genetics. 2022;8(4):e200012.
Blackstone C, O'Kane CJ. Hereditary spastic paraplegias: membrane traffic and the motor pathway. Nature Reviews Neuroscience. 2019;20(5):290-305.
Marti LG, Fernandez-Vizarra E, захаров А. Autosomal recessive hereditary spastic paraplegia with thin corpus callosum: clinical and genetic characterization. Brain. 2020;143(8):2488-2499.
Kara E, Tucci A, Bettencourt C. Genetic and phenotypic characterization of complex hereditary spastic paraplegias. Movement Disorders. 2021;36(5):1245-1258.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy