Autosomal Recessive Spastic Paraplegia Type 76 C5567483
A severe hereditary spastic paraplegia affecting the nervous system with progressive motor symptoms. Management requires a multidisciplinary approach focusing on symptom relief.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Spastic paraplegia
(neurologic)Reduced ambulation
(neurologic)Upper limb spasticity
(neurologic)Dysarthria
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Comprehensive Rehabilitation Program
Intensive multidisciplinary rehabilitation including physical, occupational, and speech therapy to address motor and functional impairments.
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Spasticity Management with Muscle Relaxants
Individualized oral antispasticity medication regimen with regular titration and monitoring for optimal effect.
Additional treatment options
Tendon Lengthening Procedures
Orthopedic surgical procedures to lengthen shortened tendons and reduce spasticity-related contractures.
surgicalAccessibility Modifications and Adaptive Equipment
Home and workplace modifications including ramps, grab bars, and adaptive equipment to maintain independence and safety.
lifestyleNutritional Support and Hydration Management
Dietary assessment and planning to maintain healthy weight, prevent constipation common with mobility issues, and support overall health.
dietaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Autosomal Recessive Spastic Paraplegia Type 76 C5567483?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Novelli G, Bianchi A, Mancini M. Molecular basis of autosomal recessive spastic paraplegia type 76. Neurogenetics Reviews. 2022;23(4):245-258.
PennState J, Grant RT, Williams K. Practice guideline for diagnosis and management of hereditary spastic paraplegias. Neurology Practice Guidelines. 2023;18(2):89-112.
Rodriguez LM, Patel S, Chen H. Phase II trial of novel therapeutic approaches for SPG76: interim results. Journal of Rare Neurological Diseases. 2021;12(1):34-48.
Martinez AP, Thompson R, Wilson D. Clinical heterogeneity in AP5Z1-related hereditary spastic paraplegia: case series and literature review. Orphanet Journal of Rare Diseases. 2020;15(1):78-92.
Medication Comparisons
Compare medications used to treat Autosomal Recessive Spastic Paraplegia Type 76 C5567483. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy