B Cell Chronic Lymphocytic Leukemia C0023434
A slow-growing blood and bone marrow cancer affecting white blood cells, most common in older adults. Many patients initially require only monitoring while others may need chemotherapy or targeted therapies. The outlook varies based on disease progression.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue
(hematologic)Generalized symptoms
(oncologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Lymphadenopathy
(hematologic)Night sweats
(hematologic)Recurrent infections
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Chemoimmunotherapy
Combination therapy using monoclonal antibodies targeting CD20 along with chemotherapy agents represents standard treatment for fit patients requiring active therapy for CLL.
Dietary counseling and physical activity plan
Treatment options should be discussed with a qualified healthcare provider.
Watchful Waiting
Active surveillance without immediate treatment is appropriate for early-stage asymptomatic CLL, with regular monitoring of blood counts and disease-related symptoms.
Additional treatment options
Targeted Therapy Agents
BTK inhibitors and BCL-2 inhibitors offer chemotherapy-free options that are particularly valuable for older patients or those with comorbidities.
medicationAllogeneic Stem Cell Transplant
Potentially curative approach for eligible patients with high-risk disease or relapsed/refractory CLL, involving conditioning chemotherapy followed by donor stem cell infusion.
procedureInfection Prevention
Lifestyle modifications including meticulous hand hygiene, food safety practices, vaccination updates, and avoidance of sick contacts to reduce infection risk in immunocompromised patients.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is B Cell Chronic Lymphocytic Leukemia C0023434?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Hallek M, Shanafelt TD, Eichhorst B. Chronic lymphocytic leukaemia: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2023.
Burger JA, Montserrat E. Mechanisms of B-cell receptor signaling in chronic lymphocytic leukemia. Blood Rev. 2022.
Fischer K, Al-Sawaf O, Bahlo J. Venetoclax and Obinutuzumab in Patients with CLL and Comorbidities. N Engl J Med. 2021.
Stilgenbauer S, Furstenau M, Zenz T. Ibrutinib in Relapsed Chronic Lymphocytic Leukemia: A Systematic Review and Meta-Analysis. J Clin Oncol. 2020.
Medication Comparisons
Compare medications used to treat B Cell Chronic Lymphocytic Leukemia C0023434. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy