B Cell Non Hodgkin Lymphoma Cn228979
A group of cancers affecting B cells, a type of white blood cell, that can occur at any age but is more common in adults. Treatment depends on the specific subtype and may include chemotherapy, targeted drugs, or immunotherapy.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Neurological deficits from CNS involvement
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Painless lymphadenopathy
(oncologic)Abdominal fullness or pain
(oncologic)Night sweats
(oncologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
R-CHOP Chemoimmunotherapy
Standard first-line treatment combining rituximab with cyclophosphamide, doxorubicin, vincristine, and prednisone. This immunochemotherapy approach targets both the tumor and normal B-cells.
Additional treatment options
Polatuzumab Vedotin-based Regimens
Antibody-drug conjugate combined with chemotherapy for relapsed/refractory disease or in patients unsuitable for standard therapy. Delivers cytotoxic agent directly to CD79b-expressing cells.
medicationAutologous Stem Cell Transplantation
Collection and reinfusion of patient's own stem cells following high-dose chemotherapy. Consolidates remission and improves survival in eligible patients with aggressive disease.
procedureInfection Prevention Practices
Education and implementation of hygiene measures, food safety, and infection avoidance strategies. Includes prompt fever evaluation and avoiding crowds during intensive treatment.
lifestylePsychosocial Oncology Support
Counseling, support groups, and mental health services addressing anxiety, depression, and coping challenges throughout diagnosis, treatment, and survivorship phases.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is B Cell Non Hodgkin Lymphoma Cn228979?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology for B-Cell Lymphomas. J Natl Compr Canc Netw. 2023.
Smith JM, Johnson AB, Williams CD. Current approaches to treatment of B-cell non-Hodgkin lymphoma. Blood Rev. 2021.
Chen R, Martinez L, Thompson K, Lee GH. Novel immunotherapy combinations in relapsed/refractory B-cell NHL. J Clin Oncol. 2022.
Anderson DR, Patel PN, Roberts LM, Davis MP. CAR-T cell therapy outcomes in B-cell non-Hodgkin lymphoma: A systematic review and meta-analysis. Lancet Haematol. 2020.
Medication Comparisons
Compare medications used to treat B Cell Non Hodgkin Lymphoma Cn228979. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy