B Cell Non Hodgkin Lymphoma High Grade Cn301216
A fast-growing form of non-Hodgkin lymphoma arising from B cells. It typically requires aggressive chemotherapy and may need stem cell transplantation. Prompt treatment is essential due to rapid progression.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Rapidly progressive lymphadenopathy
Spinal cord compression due to epidural mass
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
B symptoms (fever, night sweats, weight loss)
(oncologic)Bone marrow involvement with cytopenias
(oncologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
R-CHOP Chemotherapy
Combination chemotherapy using rituximab with cyclophosphamide, doxorubicin, vincristine, and prednisone. This multi-agent regimen targets rapidly dividing cancer cells and is the standard first-line approach for aggressive B-cell non-Hodgkin lymphoma.
Immunotherapy with Anti-CD20 Antibodies
Monoclonal antibody therapy that targets CD20 proteins on B-cell lymphoma surfaces, marking cancer cells for immune destruction. Often combined with chemotherapy for enhanced efficacy in high-grade cases.
Additional treatment options
Radiation Therapy
Targeted high-energy radiation to eliminate remaining cancer cells after chemotherapy, particularly useful for localized disease sites. May be employed as primary treatment for early-stage presentations.
procedureAutologous Stem Cell Transplant
High-dose chemotherapy followed by reinfusion of patient's own stem cells to restore bone marrow function. Considered for patients who achieve remission but face high risk of relapse.
surgicalSurveillance and Response Assessment
Regular imaging studies and laboratory tests to monitor treatment response and detect early relapse. Includes PET-CT scans and surveillance bone marrow evaluation as clinically indicated.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is B Cell Non Hodgkin Lymphoma High Grade Cn301216?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Zelenetz AD, Gordon LI, Abramson JS, et al. NCCN Guidelines Insights: B-Cell Lymphomas, Version 4.2021. J Natl Compr Canc Netw. 2021.
Swerdlow SH, Campo E, Pileri SA, et al. The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood. 2016.
Dunleavy K, Pittaluga S, Maeda LS, et al. Dose-adjusted EPOCH-rituximab therapy in primary mediastinal B-cell lymphoma. N Engl J Med. 2013.
Koch P, Bestedt K, Willenbrock K, et al. High-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements: a systematic review and meta-analysis of treatment outcomes. Lancet Haematol. 2020.
Medication Comparisons
Compare medications used to treat B Cell Non Hodgkin Lymphoma High Grade Cn301216. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy