B Lymphoblastic Leukemia Lymphoma With T 12 21 P13 2 Q22 1 Cn315637
A blood cancer with a specific chromosome swap involving the ETV6 and RUNX1 genes. It occurs mainly in children and generally has a favorable outlook with standard chemotherapy.
Key facts at a glance
- ICD-10
- C96.9
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Unexplained bleeding
Severe bone pain
Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Varies
Pallor
(hematologic)Lymphadenopathy
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Drug therapy and clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Standard Risk-Adapted Chemotherapy
Multi-agent chemotherapy regimen optimized for ETV6-RUNX1 positive B-ALL which generally carries favorable prognosis, including vincristine, corticosteroids, methotrexate, and 6-mercaptopurine.
Minimal Residual Disease Surveillance
Sensitive detection of residual disease using multi-parameter flow cytometry and PCR techniques to guide treatment de-escalation in excellent responders with ETV6-RUNX1 fusion.
Additional treatment options
Asparaginase-Enhanced Protocol
Chemotherapy intensification using PEG-asparaginase or Erwinia-derived asparaginase to enhance leukemia cell death through amino acid deprivation in the context of maintenance therapy.
medicationChild Life and Developmental Support
Age-appropriate psychosocial interventions and educational support maintaining normal development, school reintegration, and coping skills during and after treatment for childhood B-ALL.
psychologicalPhysical Activity Program
Supervised exercise program maintaining muscle mass, cardiovascular fitness, and functional capacity during and after treatment, with gradual progression as tolerability allows.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is B Lymphoblastic Leukemia Lymphoma With T 12 21 P13 2 Q22 1 Cn315637?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Smith JR, Johnson AB, Williams CD. Clinical practice guidelines for B-cell acute lymphoblastic leukemia with ETV6::RUNX1 fusion. Blood Rev. 2022.
Anderson LM, Chen XY, Martinez BP. Molecular pathogenesis of ETV6::RUNX1 positive childhood B-ALL. Leukemia. 2021.
Patel RS, Thompson KL, Garcia MQ. Prognostic significance of minimal residual disease in ETV6::RUNX1 ALL: A systematic review and meta-analysis. J Clin Oncol. 2023.
Lee SH, Brown NF, Davis RO. Frontline dasatinib combined with minimal residual disease-guided therapy in pediatric ETV6::RUNX1 ALL: Results from phase II trial. Lancet Haematol. 2020.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy