B Lymphoblastic Leukemia Lymphoma With T 17 19 C5856321
A rare leukemia with a chromosome 17 and 19 rearrangement. It most often affects children and young people and is considered high-risk, requiring intensive treatment.
Key facts at a glance
- ICD-10
- C96.9
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Mucosal bleeding
Bone pain
Fatigue and weakness
(hematologic)Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Varies
Splenomegaly
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Medication management with follow-up
Active treatment with regular monitoring by a healthcare provider is recommended.
Multi-agent Induction Chemotherapy
Intensive multi-drug chemotherapy protocol combining corticosteroids, vincristine, anthracyclines, and cyclophosphamide to achieve rapid disease remission in bone marrow.
Consolidation and Maintenance Chemotherapy
Prolonged chemotherapy regimen including high-dose methotrexate, 6-mercaptopurine, and periodic vincristine pulses to eliminate residual leukemic cells and prevent relapse.
Additional treatment options
Allogeneic Stem Cell Transplantation
High-dose chemotherapy followed by infusion of donor hematopoietic stem cells to provide graft-versus-leukemia effect and restore normal hematopoiesis.
procedureTargeted Biologic Therapy
Monoclonal antibodies such as rituximab or inotuzumab ozogamicin targeting specific surface antigens on B-lymphoblasts to enhance immune-mediated cytotoxicity.
medicationMinimal Residual Disease Monitoring
Serial molecular and flow cytometry assessments to detect residual leukemia at levels undetectable by conventional morphology, guiding treatment intensity decisions.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is B Lymphoblastic Leukemia Lymphoma With T 17 19 C5856321?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Brown PA, Shah B, Advani A, et al. NCCN Guidelines Version 3.2023: Acute Lymphoblastic Leukemia. J Natl Compr Canc Netw. 2023.
Inaba H, Mullighan CG. Pediatric acute lymphoblastic leukemia: update on epidemiology, genetic risk stratification, and targeted therapy. Haematologica. 2021.
Hunger SP, S址a XG, Pui CH, et al. Clinical outcomes and molecular characterization of E2A-HLF-positive B-cell acute lymphoblastic leukemia in children. Blood. 2019.
Roberts KG, Mullighan CG. Genomics in acute lymphoblastic leukaemia: insights and clinical implications. Lancet Haematol. 2020.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy