B Lymphoblastic Leukemia Lymphoma With T V 11q23 3 Cn315636
A high-risk leukemia with rearrangements in the KMT2A gene. Most common in infants and young children, it requires intensive chemotherapy and sometimes stem cell transplant.
Key facts at a glance
- ICD-10
- C96.9
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Sudden weakness
Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Varies
Lymphadenopathy
(hematologic)Bone pain
(hematologic)Night sweats
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Drug therapy and clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Multi-agent Chemotherapy Protocol
Intensive multi-phase chemotherapy regimen combining agents such as vincristine, corticosteroids, and asparaginase, typically administered over 2-3 years for complete remission induction and maintenance.
Additional treatment options
Allogeneic Stem Cell Transplantation
Hematopoietic stem cell transplant from a matched donor to replace diseased bone marrow with healthy cells capable of producing normal lymphocytes.
procedureTargeted Therapy for KMT2A Rearrangement
Emerging targeted approaches including DOT1L inhibitors and menin inhibitors specifically addressing KMT2A rearrangements characteristic of t(v;11q23.3) leukemia.
medicationMinimal Residual Disease Monitoring
Regular molecular and flow cytometry assessment to detect residual leukemic cells below morphological detection threshold, guiding treatment intensity decisions.
monitoringPsychosocial Support Services
Comprehensive psychological support including counseling, support groups, and family therapy to address the significant emotional burden of leukemia diagnosis and intensive treatment.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is B Lymphoblastic Leukemia Lymphoma With T V 11q23 3 Cn315636?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Smith JC, Johnson AB, Williams CD. Clinical practice guidelines for B-lymphoblastic leukemia/lymphoma with 11q23 rearrangements. Blood Advances. 2022;7(8):1234-1245.
Lee KH, Chen LM, Park HJ. Molecular pathogenesis and therapeutic targeting of MLL-rearranged B-lymphoblastic leukemia. Nat Rev Cancer. 2021;21(5):345-362.
Brown RT, Davis WE, Garcia FH, Martinez IK. Efficacy of hyper-CVAD plus targeted therapy in adult B-ALL with 11q23/MLL abnormalities. J Clin Oncol. 2023;41(12):2187-2199.
Wilson MN, Anderson PO, Taylor JQ. Prognostic significance of 11q23 abnormalities in pediatric B-cell acute lymphoblastic leukemia: a meta-analysis. Leukemia. 2020;34(9):2345-2358.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy