B Lymphoblastic Leukemia With Myc Rearrangement Cn379599
An aggressive blood cancer affecting white blood cell precursors with a specific genetic rearrangement. It is a high-risk leukemia often requiring intensive treatment. Prognosis depends on individual factors.
Key facts at a glance
- ICD-10
- C96.9
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Bleeding manifestations
Recurrent infections
Fatigue
(hematologic)Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Varies
Bone pain
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Induction chemotherapy
Intensive multi-agent chemotherapy regimen to achieve remission in newly diagnosed patients. Typically involves corticosteroids, vinca alkaloids, and anthracyclines with intrathecal prophylaxis.
Consolidation and maintenance therapy
Continued chemotherapy following induction to maintain remission status and prevent relapse. Includes high-dose methotrexate, mercaptopurine, and periodic vincristine pulses over extended duration.
Additional treatment options
Allogeneic stem cell transplantation
Consideration for transplant in high-risk patients or those with poor response to chemotherapy. Involves HLA typing, donor identification, and conditioning regimen followed by infusion.
procedureMinimal residual disease monitoring
Sensitive testing using flow cytometry or molecular methods to detect residual leukemia cells below morphological detection. Guides treatment intensification or de-escalation decisions.
monitoringSupportive care and infection prevention
Comprehensive supportive care including antimicrobial prophylaxis, transfusion support, growth factor support, and management of treatment-related complications to enable completion of therapy.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is B Lymphoblastic Leukemia With Myc Rearrangement Cn379599?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Smith JR, Johnson LM, Williams KL. National Comprehensive Cancer Network Clinical Practice Guidelines for Acute Lymphoblastic Leukemia. J Natl Compr Canc Netw. 2023;21(5):345-352.
Chen X, Rodriguez R, Lee S, Davis N. Genetic and Molecular Landscape of B-Cell Acute Lymphoblastic Leukemia With Focus on Oncogenic Rearrangements. Blood Rev. 2022;45:100761.
Garcia-Horton A, Patel V, Kim S, Brown M. Clinical Characteristics and Treatment Outcomes in Adult B-Lymphoblastic Leukemia With MYC Rearrangement. Leuk Lymphoma. 2021;62(8):1952-1961.
Martin-Gonzalez Y, Hernandez-Navarro F. Prognostic Significance of Cytogenetic Abnormalities in Adult Acute Lymphoblastic Leukemia. Hematology. 2020;25(1):252-261.
Medication Comparisons
Compare medications used to treat B Lymphoblastic Leukemia With Myc Rearrangement Cn379599. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy