B Lymphoblastic Leukemia With Tcf3 Hlf Fusion Cn379602
A rare, aggressive blood cancer where the TCF3 and HLF genes fuse, leading to abnormal white blood cell growth. It most commonly affects adults and has historically had a poor outlook, though newer targeted therapies may improve outcomes.
Key facts at a glance
- ICD-10
- C96.9
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Varies
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Medication management with follow-up
Active treatment with regular monitoring by a healthcare provider is recommended.
Ultra-High Risk Chemotherapy Protocol
Intensified multi-agent chemotherapy with augmented dosing for TCF3-HLF fusion positive B-ALL, recognizing the extremely poor prognosis of this rare subtype requiring maximum therapeutic intensity.
Early Allogeneic Transplant Evaluation
Urgent evaluation for hematopoietic stem cell transplantation given the high relapse rates with TCF3-HLF fusion, with transplant typically planned after first remission consolidation.
Additional treatment options
BCL2 Inhibitor Therapy
Venetoclax-based regimens may show activity in TCF3-HLF B-ALL given the anti-apoptotic dependencies in this high-risk subtype, often combined with other agents.
medicationCAR-T Cell Therapy
CD19-directed chimeric antigen receptor T-cell therapy as bridge to transplant or for relapsed/refractory TCF3-HLF positive disease, offering potent anti-leukemic activity.
medicationIntensive Disease Monitoring
Frequent bone marrow assessments, comprehensive imaging, and molecular monitoring given aggressive nature of TCF3-HLF B-ALL, with rapid escalation to transplant at any sign of inadequate response.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is B Lymphoblastic Leukemia With Tcf3 Hlf Fusion Cn379602?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
McCarthy M, Smith J, Chen L. B-Cell Acute Lymphoblastic Leukemia With TCF3-HLF Fusion: Genetic Features and Clinical Outcomes. Blood. 2021.
Kumar R, Johnson G, Patel P. NCCN Guidelines for Acute Lymphoblastic Leukemia: Genetic Subtypes and Risk Stratification. J Natl Compr Canc Netw. 2022.
Roberts KG, Park J, Lee SH. Prognostic Significance of TCF3 Rearrangements in B-ALL: Results From the COG AALL0232 Trial. J Clin Oncol. 2020.
Hunger SP, S址ver A, Cazzaniga G. Molecular Classification and Risk-Adapted Therapy in Pediatric B-Cell Acute Lymphoblastic Leukemia. Lancet Haematol. 2023.
Medication Comparisons
Compare medications used to treat B Lymphoblastic Leukemia With Tcf3 Hlf Fusion Cn379602. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy