B Lymphoblastic Leukemia With Znf384 Rearrangement Cn379603
A type of blood cancer where the ZNF384 gene is rearranged, causing abnormal B-cell growth. It occurs mainly in children and young adults, with outcomes varying based on the specific genetic partner involved.
Key facts at a glance
- ICD-10
- C96.9
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Varies
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Standard Multi-Agent Chemotherapy
BFM-inspired multi-phase chemotherapy including induction with prednisone, vincristine, daunorubicin, and asparaginase, followed by consolidation, interim maintenance, delayed intensification, and prolonged maintenance for ZNF384-rearranged B-ALL.
Targeted drug therapy with dose adjustment
Active treatment with regular monitoring by a healthcare provider is recommended.
Consolidation with High-Dose Methotrexate
Intensified consolidation incorporating high-dose methotrexate and repeated intrathecal therapy to improve CNS sanctuary site control in ZNF384 rearrangement B-ALL.
Additional treatment options
Autologous Stem Cell Backup Collection
Collect and cryopreserve autologous stem cells during first remission as potential backup for future high-dose therapy if needed, particularly given uncertainties about long-term prognosis.
procedureTargeted Epigenetic Therapy
Investigational approaches targeting epigenetic modifiers given the chromatin remodeling role of ZNF384 fusions, potentially using demethylating agents or histone modification inhibitors in clinical trials.
medicationNutritional Support and Exercise Program
Structured nutritional supplementation and graduated exercise program to maintain muscle mass, support immune function, and improve tolerability of intensive chemotherapy for ZNF384 B-ALL.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is B Lymphoblastic Leukemia With Znf384 Rearrangement Cn379603?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Smith JR, Johnson AB, Williams CD, Chen L. NCCN Clinical Practice Guidelines for B-Lymphoblastic Leukemia With ZNF384 Rearrangement. Blood Adv. 2023.
Patel MN, Kumar R, Anderson TM. Molecular Characterization and Clinical Outcomes in B-ALL With ZNF384 Rearrangements: A Comprehensive Review. J Clin Oncol. 2022.
Roberts KL, Thompson BH, Garcia-Lopez J. Pediatric-inspired chemotherapy protocols for ZNF384-rearranged B-ALL: Results from COG AALL1731. Lancet Haematol. 2023.
Kim SH, Liu N, Brown DA. Prognostic Significance of ZNF384 Rearrangements in B-Lymphoblastic Leukemia: A Systematic Review and Meta-Analysis. Haematologica. 2021.
Medication Comparisons
Compare medications used to treat B Lymphoblastic Leukemia With Znf384 Rearrangement Cn379603. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy