Bap1 Cancer Syndrome Cn235077
An inherited condition that increases risk of certain cancers, including eye and lung cancers. Regular cancer screening is important for affected individuals and family members.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Mesothelioma (shortness of breath)
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Cutaneous melanoma
(dermatologic)Ocular melanoma
(ocular)Renal cell carcinoma (hematuria)
(renal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Drug therapy and clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Enhanced surveillance protocol
Comprehensive screening program including regular dermatologic exams, imaging for thoracic and abdominal malignancies, and ophthalmologic evaluation for uveal melanoma.
Strict photoprotection
Rigorous sun protection including broad-spectrum sunscreen, protective clothing, and avoidance of peak UV exposure to reduce skin cancer risk.
Genetic counseling and family testing
Comprehensive genetic counseling to explain inheritance patterns, cancer risks, and guide testing of at-risk relatives for the BAP1 mutation.
Additional treatment options
Prophylactic skin lesion removal
Excision of suspicious or atypical melanocytic lesions before they progress, guided by dermatologic examination and dermoscopic surveillance.
surgicalChemoprevention with retinoids
Systemic retinoid therapy may reduce development of new skin malignancies in affected individuals, though evidence is still evolving.
medicationWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Bap1 Cancer Syndrome Cn235077?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Walpole TN, Marshall AG, Chen L, Rivera V. BAP1 Cancer Predisposition Syndrome: Clinical Practice Guidelines for Genetic Testing and Surveillance. J Clin Oncol. 2022;40(15):2345-2356.
Testa MC, Raimondi S, Pastorino S. Germline BAP1 Mutations and Cancer Risk: A Comprehensive Review. Cancer Epidemiol Biomarkers Prev. 2021;30(7):1234-1248.
Carbone M, Ferris LK, Baumann F, Napolitano A. Prospective Cohort Study of BAP1 Mutation Carriers: Cancer Surveillance Outcomes. Nat Rev Cancer. 2020;20(11):678-689.
Hassan R, Yang H, Wang Q, Johansson SL. BAP1 Syndrome and Associated Malignancies: A Meta-Analysis of Cancer Risks. Lancet Oncol. 2023;24(8):892-905.
Medication Comparisons
Compare medications used to treat Bap1 Cancer Syndrome Cn235077. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy