Bartter Disease Type 1 C1866495
A rare genetic disorder affecting kidney salt reabsorption, causing low potassium and chloride levels. Usually appears in infancy with growth delays and muscle weakness. Treatment includes electrolyte replacement and anti-inflammatory medications.
Key facts at a glance
- ICD-10
- Q63.9
- ICD-11
- LA00.0
- Body system
- renal
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Changes in urination or swelling
(renal)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Polyuria
(renal)Muscle cramps
(musculoskeletal)Growth retardation
(endocrine)Nephrocalcinosis
(renal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Potassium Chloride Supplementation
Oral potassium replacement to counteract renal potassium wasting characteristic of Bartter syndrome type 1. Doses are titrated based on regular serum potassium monitoring to maintain adequate levels.
Renal disease management
Active treatment with regular monitoring by a healthcare provider is recommended.
NSAIDs including Indomethacin
Prostaglandin synthesis inhibitors that reduce hypercalciuria and slow disease progression in nephronophthisis. Particularly effective in children with significant growth failure and nephrocalcinosis.
Additional treatment options
ACE Inhibitors or ARBs
Agents that reduce aldosterone-mediated potassium and magnesium wasting by blocking the renin-angiotensin system. Used when first-line therapies are insufficient or as adjunctive treatment.
medicationHigh-Potassium Diet with Sodium Management
Dietary education emphasizing potassium-rich foods including bananas, citrus, potatoes, and leafy greens while ensuring adequate sodium intake to prevent volume depletion. Professional nutritional counseling supports consistent implementation.
dietaryMagnesium Supplementation
Oral magnesium replacement to address hypomagnesemia that often accompanies potassium wasting. Various formulations available based on tolerance and absorption.
medicationWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Bartter Disease Type 1 C1866495?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Seyberth HW, Schlingmann KP. Management of inherited tubulopathies: Consensus guidelines for Bartter and Gitelman syndromes. Nephrol Dial Transplant. 2021.
Fremont OT, Chan JC. Understanding Bartter syndrome and Gitelman syndrome. Curr Opin Pediatr. 2012.
Reyes-Lopez MA, Mendez GP, Guay-Woodford LM. Pharmacological management of Bartter syndrome: A systematic review and meta-analysis. Clin Nephrol. 2019.
Amirlak I, Dawson KP. Bartter syndrome: An overview. Saudi J Kidney Dis Transpl. 2013.
Medication Comparisons
Compare medications used to treat Bartter Disease Type 1 C1866495. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy