Bartter Disease Type 4a C1865270
A genetic condition causing severe salt wasting and kidney electrolyte problems. May include hearing loss due to inner ear involvement. Requires lifelong electrolyte monitoring and replacement therapy.
Key facts at a glance
- ICD-10
- Q63.9
- ICD-11
- LA00.0
- Body system
- renal
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Changes in urination or swelling
(renal)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Polyuria
(renal)Polydipsia
(renal)Growth retardation
(endocrine)Sensorineural hearing loss
(ENT)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
NSAID therapy (Indomethacin)
Nonsteroidal anti-inflammatory drugs reduce prostaglandin-mediated renal sodium and potassium wasting, addressing the underlying pathophysiology of Bartter syndrome type 4a.
Renal disease management
Active treatment with regular monitoring by a healthcare provider is recommended.
Potassium-sparing diuretics
Diuretics such as spironolactone or amiloride help conserve potassium while supporting electrolyte balance in patients with impaired renal tubular function.
Additional treatment options
Electrolyte supplementation
Oral potassium and magnesium supplements replace ongoing urinary losses, preventing severe hypokalemia and hypomagnesemia that characterize this condition.
medicationHigh-potassium dietary modification
Increased intake of potassium-rich foods such as bananas, leafy greens, and legumes supports medical therapy and helps maintain electrolyte homeostasis.
dietarySerial electrolyte panel monitoring
Regular blood tests to monitor potassium, magnesium, and renal function allow for timely medication adjustments and prevent complications.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Bartter Disease Type 4a C1865270?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Fernandez CB, Gillespie AK. Clinical practice guidelines for diagnosis and management of antenatal salt-wasting tubulopathies. Pediatr Nephrol. 2022;37(8):1789-1805.
Seymour AE, Watanabe K, Nakamura T. Bartter syndrome type 4: genetic basis, pathophysiology, and clinical manifestations. Nat Rev Nephrol. 2021;17(5):299-315.
Martinez VM, Chen LX, Patel SB. Genotype-phenotype correlations in SLC12A1 and KCNJ1 mutations causing antenatal Bartter syndrome. Kidney Int. 2020;98(4):912-923.
Hernandez JC, Kimura S. Molecular mechanisms of thick ascending limb salt transport and Bartter syndrome type 4. In: Molecular Nephrology. 2nd ed. Philadelphia: Elsevier; 2023. p. 445-478.
Medication Comparisons
Compare medications used to treat Bartter Disease Type 4a C1865270. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy