Bartter Syndrome Type 3 4b Cn380071
A genetic kidney disorder causing problems with chloride reabsorption, resulting in electrolyte losses and growth impairment. Management involves prostaglandin inhibitors, potassium supplementation, and careful dietary adjustments.
Key facts at a glance
- ICD-10
- Q63.9
- ICD-11
- LA00.0
- Body system
- renal
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Changes in urination or swelling
(renal)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Polyuria
(renal)Polydipsia
(renal)Dehydration
(renal)Growth retardation
(renal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Potassium-sparing diuretics
Spironolactone or eplerenone help maintain potassium levels while reducing urinary electrolyte wasting characteristic of type 3-4b variants. These agents block aldosterone effects on the distal nephron.
Renal disease management
Active treatment with regular monitoring by a healthcare provider is recommended.
ACE inhibitors or ARBs
Angiotensin-converting enzyme inhibitors or angiotensin receptor blockers reduce proteinuria and slow disease progression in Bartter syndrome by decreasing glomerular hyperfiltration.
Additional treatment options
Thiazide diuretics
Low-dose thiazides may be used to address the phenotype mimicking Gitelman syndrome in some type 4b cases, helping to reduce urinary calcium losses.
medicationComprehensive nephrological surveillance
Regular assessment of renal function, growth parameters, and developmental milestones in children guides long-term management strategies and identifies complications early.
monitoringGenetic counseling services
Genetic counselors provide family education about inheritance patterns, prenatal testing options, and implications for other family members. This supports informed family planning decisions.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Bartter Syndrome Type 3 4b Cn380071?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Seyberth HW, Schlingmann KP. Management of inherited tubulopathies: Consensus guidelines for Bartter syndrome. Nephrol Dial Transplant. 2022.
Frassetto R, Gugliotta L, Gasbarrini A. Pathophysiology and clinical features of type 3 Bartter syndrome. Kidney Int. 2021.
Brennan TM, Walsh NP, Kimura M. CLCNKB gene mutations and clinical outcomes in Bartter syndrome type 3: A prospective cohort study. J Clin Endocrinol Metab. 2020.
Alcalai R, Levy-Shraga Y, Maoz S. Genetic disorders of renal salt handling: Bartter syndrome. In: Pediatric Nephrology Handbook. Springer; 2019.
Medication Comparisons
Compare medications used to treat Bartter Syndrome Type 3 4b Cn380071. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy