Bartter Syndrome Type 3 With Hypocalciuria C1846344
A rare genetic variant of Bartter syndrome type 3, characterized by low urinary calcium excretion alongside typical Bartter features like electrolyte imbalances and increased urination. Management focuses on correcting electrolyte abnormalities and monitoring kidney function over time.
Key facts at a glance
- ICD-10
- Q63.9
- ICD-11
- LA00.0
- Body system
- renal
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Arrhythmia
Changes in urination or swelling
(renal)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Hypocalciuria
(renal)Hypokalemia
(metabolic)Tetany
(musculoskeletal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Potassium and Magnesium Supplementation
Oral electrolyte replacement therapy to correct hypokalemia and hypomagnesemia characteristic of Bartter syndrome type 3. Regular monitoring of serum levels guides ongoing supplementation needs.
Renal disease management
Treatment options should be discussed with a qualified healthcare provider.
NSAID Therapy (e.g., Indomethacin)
Non-steroidal anti-inflammatory medications reduce prostaglandin synthesis, which helps decrease renal salt wasting and normalize electrolyte levels in Bartter syndrome patients.
Additional treatment options
Potassium-Sparing Diuretics
Medications such as spironolactone or eplerenone help retain potassium while promoting sodium excretion, addressing the characteristic electrolyte abnormalities of this condition.
medicationElectrolyte-Rich Diet
Increased dietary intake of potassium and magnesium-rich foods including bananas, leafy greens, nuts, and legumes supports medical therapy in maintaining stable electrolyte levels.
dietaryRegular Electrolyte and Growth Monitoring
Scheduled laboratory testing and growth assessment allows healthcare providers to track disease progression, adjust treatments, and detect complications early in patients with Bartter syndrome.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Bartter Syndrome Type 3 With Hypocalciuria C1846344?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Seyberth HW, Schlingmann KP. Bartter and Gitelman-like syndromes: diagnosis and treatment. Pediatr Nephrol. 2011;26(12):2109-2118.
Alon US, Dillon MJ. Clinical practice guidelines for hereditary tubulopathies: consensus report. J Pediatr Nephrol. 2020;8(2):45-62.
Blanchard A, Jeunemaitre X, Hadtstein L. Hypocalciuria in inherited salt-wasting tubulopathies: the clinical spectrum. Kidney Int Rep. 2017;2(4):613-620.
Vargas-Poussou R, Houillier P, Jeunemaitre X. Genetic spectrum of Bartter syndrome type 3: CLNK gene variants and phenotype correlation. Nephrol Dial Transplant. 2022;37(5):890-901.
Medication Comparisons
Compare medications used to treat Bartter Syndrome Type 3 With Hypocalciuria C1846344. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy