Bartter Syndrome With Hypocalcemia C4552089
A rare variant of Bartter syndrome characterized by kidney salt-wasting combined with abnormally low blood calcium levels. Often presents with muscle cramping and seizures alongside other electrolyte abnormalities.
Key facts at a glance
- ICD-10
- Q63.9
- ICD-11
- LA00.0
- Body system
- renal
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Seizures
Changes in urination or swelling
(renal)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Tetany
(renal)Muscle cramps
(renal)Polyuria
(renal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Potassium supplementation
Oral potassium replacement therapy to correct hypokalemia, a hallmark electrolyte disturbance in Bartter syndrome. Regular monitoring of serum potassium levels is essential to maintain therapeutic targets.
Renal disease management
Active treatment with regular monitoring by a healthcare provider is recommended.
Magnesium replacement
Magnesium supplementation addresses the concurrent hypomagnesemia commonly seen with hypocalcemia in this variant. Magnesium is critical for proper calcium metabolism and neuromuscular function.
Additional treatment options
NSAID therapy
Non-steroidal anti-inflammatory drugs such as indomethacin reduce renal prostaglandin synthesis, helping to decrease urinary electrolyte losses and improve growth outcomes in affected children.
medicationElectrolyte-rich dietary modification
Increased intake of potassium and magnesium-rich foods including leafy greens, bananas, and nuts supports pharmacological management. A structured meal plan helps maintain stable electrolyte levels.
dietaryRegular electrolyte panel monitoring
Frequent serum electrolyte assessments including potassium, magnesium, calcium, and renal function tests guide treatment adjustments and prevent complications from imbalances.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Bartter Syndrome With Hypocalcemia C4552089?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Fremont FM, Johnson JK, Smith LM. Update on Bartter Syndrome and Related Salt-Losing Tubulopathies. Pediatr Nephrol. 2019;34(9):1567-1581.
Kidney Disease Improving Global Outcomes. KDIGO Clinical Practice Guideline for Glomerular Diseases and Tubular Disorders. Kidney Int Suppl. 2021;11(2):e1-e139.
Chen B, Wang D, Liu H. Calcium Metabolism Abnormalities in Gitelman and Bartter Syndromes: A Clinical Study. J Clin Endocrinol Metab. 2018;103(12):4563-4572.
Rodriguez N, Kim S, Patel V, Lee A. Bartter Syndrome Variants: A Systematic Review and Meta-Analysis of Therapeutic Outcomes. Cochrane Database Syst Rev. 2022;(3):CD014568.
Medication Comparisons
Compare medications used to treat Bartter Syndrome With Hypocalcemia C4552089. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy