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Beckwith Wiedemann Syndrome Due To 11p15 Translocation Inversion C5680920

Published: July 22, 2026Updated: August 20, 2026

A genetic overgrowth disorder caused by chromosomal rearrangement affecting the 11p15 region. Presents with accelerated growth, enlarged organs, and elevated tumor risk. Ongoing medical supervision is essential.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
Q89.9
ICD-11
LA00.0
Body system
congenital
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Generalized symptoms

(congenital)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Macroglossia (enlarged tongue)

(head_and_neck)

Neonatal hypoglycemia

(endocrine)

Renal anomalies (nephromegaly, cystic kidneys)

(genitourinary)

Increased risk of embryonal tumors (Wilms tumor, hepatoblastoma)

(oncology)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Comprehensive Tumor Surveillance

Longitudinal screening program for Wilms tumor and hepatoblastoma in patients with translocation/inversion-related BWS, with timing based on molecular findings.

monitoring
2

Lifestyle modification and dietary intervention

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
3

Macroglossia Surgical Correction

Tongue reduction surgery performed by experienced surgeons to improve functional outcomes and quality of life in affected individuals.

surgical

Additional treatment options

Neonatal Metabolic Management

Aggressive management of neonatal hypoglycemia with appropriate feeding regimens and glucose monitoring protocols.

dietary

Musculoskeletal Intervention

Physical therapy to address motor development delays and manage limb length discrepancies or body asymmetry when present.

physical_therapy

Family Counseling and Support

Psychological support and genetic counseling for families to understand the inheritance patterns and implications for family planning.

psychological

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Beckwith Wiedemann Syndrome Due To 11p15 Translocation Inversion C5680920?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Eggermann T, Perez de Nanclares G, Maher ER, et al. Imprinting disorders: a group of congenital disorders with overlapping molecular defects. Eur J Hum Genet. 2015.

review2015
2

Brioude F, Kalish JM, Mussa A, et al. Clinical and molecular diagnosis, screening and management of Beckwith-Wiedemann syndrome. Nat Rev Endocrinol. 2018.

guideline2018
3

Shuman C, Beckwith JB, Weksberg R. Beckwith-Wiedemann Syndrome. GeneReviews. 2020.

review2020View source →
4

Court F, Martin-Trujillo A, Romanelli V, et al. Genome-wide allelic methylation analysis in patients with imprinting disorders. Clin Epigenetics. 2017.

meta_analysis2017

Medication Comparisons

Compare medications used to treat Beckwith Wiedemann Syndrome Due To 11p15 Translocation Inversion C5680920. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy