Bence Jones Proteinuria C0004968
The presence of abnormal protein fragments in urine, often linked to plasma cell disorders. It primarily affects adults and requires investigation for underlying conditions. Treatment depends on the underlying cause.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Bone pain
(hematologic)Generalized symptoms
(hematologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Fatigue
(hematologic)Recurrent infections
(hematologic)Weight loss
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Chemotherapy/Immunomodulatory therapy
Treatment focuses on the underlying plasma cell dyscrasia causing Bence Jones proteinuria. Common approaches include proteasome inhibitors, immunomodulatory drugs, and corticosteroids to reduce abnormal protein production by malignant plasma cells.
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Serial serum free light chain analysis
Regular monitoring of serum free light chain levels to assess disease response and progression. This provides more sensitive detection of treatment response compared to urine protein measurements alone.
Additional treatment options
Bisphosphonate therapy
Administered to prevent skeletal-related events and reduce bone pain associated with plasma cell disorders. Helps maintain bone density and reduces fracture risk in patients with lytic lesions.
medicationRenal-protective nutritional support
Dietary modifications to support kidney function including adequate hydration, controlled protein intake as appropriate, and reduced sodium consumption. May include referral to a renal dietitian for individualized meal planning.
dietaryAdequate hydration and fluid management
Maintaining optimal hydration status helps reduce the risk of cast nephropathy and supports overall renal function. Patients are encouraged to drink adequate fluids unless contraindicated by other conditions.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Bence Jones Proteinuria C0004968?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Rajkumar SV, Dimopoulos MA, Palumbo A, et al. International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma. Lancet Oncol. 2014;15(12):e538-e548.
Hutchison CA, Batuman V, Behrens J, et al. The pathogenesis and diagnosis of acute kidney injury in multiple myeloma. Nat Rev Nephrol. 2012;8(1):43-51.
Dispenzieri A, Zhang SK, Katzmann JA, et al. Monoclonal gammopathy of undetermined significance and survival in patients with renal dysfunction. J Clin Oncol. 2018;36(9):865-873.
Leung N, Bridoux F, Batuman V, et al. The evaluation of monoclonal gammopathy of renal significance: consensus recommendations. Kidney Int. 2018;94(2):310-315.
Medication Comparisons
Compare medications used to treat Bence Jones Proteinuria C0004968. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy