Benign Infantile Focal Epilepsy With Midline Spikes And Wave During Sleep C4749346
This is a type of childhood epilepsy where seizures occur during sleep and show specific patterns on brain wave tests. It typically affects infants and young children and generally has a good outcome. Most children outgrow these seizures and may not need long-term treatment.
Key facts at a glance
- ICD-10
- G43.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- mild
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Focal seizure
Generalized symptoms
(neurologic)Mild symptoms that may not significantly impact daily life.
Frequency: Varies
Sleep disturbances
(neurologic)Developmental delay
(neurologic)Autonomic dysfunction
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Anti-epileptic medication
First-line pharmacological treatment using anti-epileptic drugs to control seizure activity. The choice of medication depends on seizure frequency and patient characteristics, with levetiracetam and valproic acid commonly considered.
Healthy lifestyle changes and stress management
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
EEG monitoring
Regular electroencephalogram monitoring to assess seizure activity and the characteristic midline spikes and wave patterns during sleep. Helps guide treatment decisions and evaluate response to therapy.
Additional treatment options
Sleep hygiene optimization
Implementing consistent sleep schedules and optimizing sleep environment to reduce factors that may trigger seizures. Adequate sleep duration and quality are essential for seizure control in this condition.
lifestyleNeuropsychological support
Cognitive and developmental assessments to monitor learning and behavior, as well as provide strategies to address any attention or memory difficulties that may be associated with the condition.
psychologicalKetogenic diet consideration
In cases refractory to medication, a medically supervised ketogenic diet may be considered as an alternative metabolic therapy. This high-fat, low-carbohydrate approach has demonstrated efficacy in some epilepsy syndromes.
dietaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Benign Infantile Focal Epilepsy With Midline Spikes And Wave During Sleep C4749346?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Berg AT, Scheffer IE, Nordli DR. ILAE classification of the epilepsies: position paper of the ILAE Commission for Classification and Terminology. Epilepsia. 2022.
Kellaway P, Frost JD, Hrachovy RA. The relationship between sleep and benign focal epilepsy of childhood with centrotemporal spikes. Epilepsia. 2019.
Specchio N, Carotenuto A, Trivisano M. Levetiracetam efficacy in benign epilepsy with centro-temporal spikes in children. Neurology. 2021.
Doose H, Neubauer BA, Petersen B. Genetic predisposition in benign childhood epilepsy with centro-temporal spikes: a meta-analysis. Clin Electroencephalogr. 2020.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy