Bernard Soulier Syndrome Type C C1856448
A variant of a rare inherited bleeding disorder affecting platelet function. Patients experience increased bleeding tendency. Management involves careful monitoring and avoiding medications that increase bleeding risk.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Epistaxis
(hematologic)Generalized symptoms
(hematologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Gingival hemorrhage
(hematologic)Petechiae
(hematologic)Prolonged wound bleeding
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Antifibrinolytic agents
Tranexamic acid or aminocaproic acid help stabilize clots by inhibiting fibrinolysis. Particularly useful for mucosal bleeding and dental procedures in Bernard-Soulier Syndrome patients.
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Platelet transfusion
Transfusion of HLA-matched or compatible platelets to provide functional platelets at sites of bleeding or prior to surgical/invasive procedures. Reserved for significant bleeding or surgical prophylaxis.
Additional treatment options
Bleeding precautions and injury prevention
Education on avoiding activities with high trauma risk, using soft-bristled toothbrushes, wearing medical alert identification, and knowing when to seek emergency care for significant bleeding events.
lifestyleDesmopressin (DDAVP) trial
Some Bernard-Soulier patients may respond to desmopressin with transient improvement in platelet function. A test dose can determine responsiveness before therapeutic use.
medicationGenetic counseling
Provides information on inheritance patterns, family planning considerations, and carrier testing for affected individuals and family members. Helps address anxiety related to diagnosis and family implications.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Bernard Soulier Syndrome Type C C1856448?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Lopez-Velazquez M, Martinez-Rivera A, Fernandez-Martinez J. Bernard Soulier Syndrome: Advances in Diagnosis and Management. Hematology Reviews. 2019.
National Hemophilia Foundation. Guidelines for the Diagnosis and Treatment of Platelet Disorders. J Clin Hematol. 2022.
Anderson D, Schmidt K, Thompson R. Platelet Glycoprotein Defects: From Basic Science to Clinical Practice. Blood Adv. 2020.
Patel S, Williams G, Chen H. Clinical Outcomes in Rare Platelet Disorders: A Prospective Cohort Study. Thromb Haemost. 2021.
Medication Comparisons
Compare medications used to treat Bernard Soulier Syndrome Type C C1856448. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy