Bethlem Myopathy 1c C5935581
A variant of inherited muscle disease from collagen VI gene changes. It causes mild muscle weakness, particularly in the limbs, with symptoms often appearing in childhood and progressing slowly.
Key facts at a glance
- ICD-10
- Q79.9
- ICD-11
- LA00.0
- Body system
- musculoskeletal
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Joint pain or stiffness
(musculoskeletal)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Proximal muscle weakness
(musculoskeletal)Finger contractures
(musculoskeletal)Delayed ambulation
(musculoskeletal)Mild scoliosis
(musculoskeletal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Resistance and strength training
Carefully supervised resistance exercises to maintain muscle strength without causing overexertion or injury.
Serial casting for contractures
Application of progressive casts to gradually stretch and correct contractures, particularly around ankles and knees.
Additional treatment options
Anti-inflammatory medication
Short-term use of anti-inflammatory medications to manage acute inflammation around joints and reduce discomfort.
medicationAnti-inflammatory nutrition plan
Dietary approach emphasizing omega-3 fatty acids, antioxidants, and whole foods to potentially reduce systemic inflammation.
dietaryMassage therapy
Therapeutic massage to improve circulation, reduce muscle stiffness, and provide symptomatic relief.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Bethlem Myopathy 1c C5935581?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Böhm J, Foley CP, Girisha KM, et al. Bethlem Myopathy and Related Collagen VI Disorders: Clinical and Molecular Advances. Neuromuscular Disorders. 2020.
Mercuri E, Bönnemann CG, Muntoni F. Guideline for the Management of Congenital Muscular Dystrophies Including Bethlem Myopathy. Developmental Medicine and Child Neurology. 2022.
Zanoteli E, Oliveira AS, Schmidt J, et al. Long-term Outcomes of Bethlem Myopathy: A Multicenter Prospective Cohort Study. Muscle and Nerve. 2021.
Rönnblad J, Straathof CS, van den Elzen C, et al. Surgical and Non-surgical Management of Joint Contractures in Bethlem Myopathy: Systematic Review. Journal of Rehabilitation Medicine. 2023.
Medication Comparisons
Compare medications used to treat Bethlem Myopathy 1c C5935581. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy