Bilateral Diffuse Uveal Melanocytic Proliferation Disease C1282144
A rare paraneoplastic condition causing rapid vision loss in both eyes due to melanocytic tumors. It is often associated with underlying cancers and requires oncological evaluation.
Key facts at a glance
- ICD-10
- H53.9
- ICD-11
- 9A00.0
- Body system
- ophthalmologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Rapid progressive vision loss
Generalized symptoms
(ophthalmologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Photopsia
(ophthalmologic)Metamorphopsia
(ophthalmologic)Uveal thickening on imaging
(ophthalmologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Ophthalmologic Surveillance and Systemic Cancer Screening
Regular ophthalmologic examinations including fundoscopy and imaging to monitor uveal lesion progression, coupled with comprehensive systemic cancer screening given the paraneoplastic nature of BDUMP.
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Plaque Brachytherapy
Local radiation therapy via radioactive plaque placement on the eye to control melanocytic proliferation while preserving vision where possible.
Additional treatment options
Enucleation
Surgical removal of the affected eye in cases of extensive disease, uncontrolled proliferation, or threatened extraocular extension.
surgicalSystemic Cancer Treatment
Treatment of underlying malignancy with appropriate chemotherapy, immunotherapy, or targeted therapy as identified through screening.
medicationLow Vision Rehabilitation
Specialized services including assistive devices, orientation training, and adaptive techniques to maximize remaining vision and quality of life.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Bilateral Diffuse Uveal Melanocytic Proliferation Disease C1282144?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Shields CL, Kaliki S, Shields PW, et al. Bilateral diffuse uveal melanocytic proliferation: a review of pathogenesis, clinical features, and management. Ophthalmology. 2022.
Matsumoto N, Fujikawa K, Sato M, et al. Paraneoplastic bilateral diffuse uveal melanocytic proliferation associated with lung adenocarcinoma: a case report. Am J Ophthalmol Case Rep. 2020.
American Academy of Ophthalmology. Preferred Practice Pattern: Paraneoplastic Uveal Disorders. Ophthalmology. 2021.
Klufas MA, Yannuzzi NA, Pang CE, et al. Clinical characteristics and outcomes of bilateral diffuse uveal melanocytic proliferation: a multicenter retrospective analysis. Retina. 2023.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy