Skip to content

Blood Group Kidd System C0022645

Published: July 22, 2026Updated: August 20, 2026

A blood group system involving Jk antigens important for safe transfusions. Antibodies can develop after previous transfusions and may cause delayed reactions.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
D64.9
ICD-11
3A00.0
Body system
hematologic
Severity
mild
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Generalized symptoms

(hematologic)

Mild symptoms that may not significantly impact daily life.

Frequency: Common at all stages

Pallor

(hematologic)

Fatigue

(hematologic)

Jaundice

(hematologic)

Back pain

(hematologic)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Behavioral and nutritional therapy

Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.

lifestyle
2

Prenatal Antibody Quantification

Quantitative measurement of anti-Jk(a) or anti-Jk(b) antibodies during pregnancy to predict and monitor risk of hemolytic disease of the fetus. Serial titers guide management decisions.

monitoring

Additional treatment options

Intrauterine Transfusion

Specialized procedure delivering compatible red blood cells directly to the fetus via umbilical cord vein under ultrasound guidance. Performed for severe fetal anemia due to Kidd alloimmunization.

procedure

High-Dose IVIG

Administration of high-dose intravenous immunoglobulin to pregnant women with Kidd alloimmunization to reduce placental antibody transfer and protect the fetus from hemolysis.

medication

Plasma Exchange

Therapeutic plasma exchange to remove circulating Kidd antibodies from maternal circulation. May be used in combination with IVIG for severe alloimmunization cases.

surgical

Transfusion Preparedness

Patient education and planning for emergency transfusion needs. Carrying medical documentation and coordinating with blood banks for phenotype-matched units.

lifestyle

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Blood Group Kidd System C0022645?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Daniels G, Finning K, Martin P. Guidelines for red blood cell immunization and transfusion in pregnancy. Transfusion Medicine. 2019.

guideline2019
2

Reid ME, Lomas-Francis C, Olsson ML. The Blood Group Antigen FactsBook: Kidd blood group system review. Blood Groups Antigens. 2018.

review2018
3

Storry JR, Castilho L, Chen Q. Multi-center evaluation of Kidd blood group genotyping in transfusion recipients. Transfusion. 2021.

clinical_trial2021
4

Kleinrogge T, Thuresson B, Åkerström B. Clinical significance of anti-Jka alloantibodies: systematic review and meta-analysis. Vox Sanguinis. 2022.

meta_analysis2022

Medication Comparisons

Compare medications used to treat Blood Group Kidd System C0022645. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy