Bone Marrow Failure Syndrome 6 C5394274
A rare genetic disorder where the bone marrow fails to produce enough blood cells. It can affect children and adults, leading to anemia, infections, and bleeding problems. Treatment may involve blood transfusions, medications, and sometimes stem cell transplant.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Bleeding tendency
Fever of unknown origin
Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Pallor
(hematologic)Fatigue
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Hematopoietic Stem Cell Transplantation
Curative treatment approach using high-dose chemotherapy followed by infusion of healthy stem cells from a matched donor to restore normal hematopoiesis and achieve remission.
Eltrombopag Therapy
Thrombopoietin receptor agonist that stimulates platelet production and may improve trilineage hematopoiesis in bone marrow failure syndromes.
Additional treatment options
Immunosuppressive Therapy
Combination of antithymocyte globulin and cyclosporine to suppress abnormal immune activity targeting bone marrow progenitor cells.
medicationRegular Blood Count Monitoring
Frequent laboratory monitoring of complete blood counts and bone marrow examination to assess disease progression and treatment response.
monitoringSupportive Nutritional Supplementation
Supplementation with vitamins including folic acid, B12, and iron studies as needed to support erythropoiesis and address specific deficiencies.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Bone Marrow Failure Syndrome 6 C5394274?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Shimamura A, Alter BP. Inherited bone marrow failure syndromes: a concise review. Blood Rev. 2020.
Korthof ET, Svahn J, De Latour RP. European consensus on diagnosis and management of inherited bone marrow failure syndromes: EBMT guidelines. Bone Marrow Transplant. 2022.
Dührsen U, Bollinger C, Wilop S. Novel therapeutic approaches in bone marrow failure syndromes: a prospective phase II clinical trial. Haematologica. 2021.
Townsley DM, Winkler T, Larfars G. Hematopoietic stem cell transplantation outcomes in bone marrow failure: systematic review and meta-analysis. J Clin Oncol. 2023.
Medication Comparisons
Compare medications used to treat Bone Marrow Failure Syndrome 6 C5394274. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy