Brittle Cornea Syndrome 1 C0268344
A rare genetic disorder causing extremely thin and fragile corneas, leading to risk of rupture. It affects connective tissue throughout the body. Management focuses on protecting the eyes from injury.
Key facts at a glance
- ICD-10
- Q15.9
- ICD-11
- LA00.0
- Body system
- ophthalmologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Corneal perforation
Corneal thinning
(ophthalmologic)Generalized symptoms
(ophthalmologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Keratoglobus
(ophthalmologic)Blue sclera
(ophthalmologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Protective eyewear
Daily use of polycarbonate protective glasses or goggles to prevent corneal trauma, which can lead to spontaneous perforation in affected individuals.
Additional treatment options
Corneal transplantation
Penetrating keratoplasty may be considered for patients with significant visual impairment or recurrent corneal perforations that cannot be managed conservatively.
surgicalEmergency tectonic graft
Urgent surgical intervention using donor tissue to restore corneal integrity following acute corneal perforation, followed by intensive topical therapy.
procedureOphthalmology follow-up
Regular slit-lamp examinations and corneal tomography to monitor thinning progression, detect early perforations, and adjust management strategy.
monitoringEnvironmental modification
Home and work environment assessment to identify and eliminate hazards that increase risk of eye trauma, including sharp corners and low-hanging obstacles.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Brittle Cornea Syndrome 1 C0268344?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy