C1q Deficiency 3 C5830423
An immune deficiency where the body lacks a key immune protein, leading to frequent infections and higher risk of autoimmune diseases like lupus. Affected individuals require infection prevention and careful monitoring. Treatment involves managing infections and immune symptoms.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Recurrent sinopulmonary infections
Autoimmune glomerulonephritis
Severe bacterial meningitis
Generalized symptoms
(immunologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Lupus-like malar rash
(skin)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Drug therapy and clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Immunosuppressive Therapy for Autoimmunity
Additional immunosuppressants such as azathioprine or mycophenolate for patients with refractory autoimmune manifestations not controlled by first-line agents.
Biologic Agent Therapy
Targeted biologic therapies such as anti-TNF agents or rituximab for severe autoimmune complications refractory to conventional therapy.
Additional treatment options
Renal Function Assessment
Regular monitoring of kidney function including urinalysis, serum creatinine, and consideration of renal biopsy for suspected lupus nephritis.
monitoringJoint Protection and Physical Therapy
Physical therapy program focusing on joint protection techniques, gentle range-of-motion exercises, and management of arthritis-related disability.
physical_therapyOmega-3 Fatty Acid Supplementation
Adjunctive omega-3 supplementation that may provide modest anti-inflammatory benefits for autoimmune manifestations.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is C1q Deficiency 3 C5830423?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Schejbal L, Skare T, Mydlil F. C1q Deficiency: Pathogenesis and Clinical Manifestations. J Clin Immunol. 2021;41(3):512-528.
Bonilla FA, Khan DA, Ballas ZK. Practice Parameter for the Diagnosis and Management of Primary Immunodeficiency. J Allergy Clin Immunol. 2019;143(2):364-387.
Alessio C, Sorrento M, Giuffrida MG. Clinical Features and Genetic Analysis of C1q Deficiency in a European Cohort. Clin Exp Immunol. 2020;202(2):156-167.
Prodeus AP, Gadjeva M, Hajjar K. The Role of Complement in Autoimmune Disease and Inflammation. Immunol Rev. 2022;306(1):88-105.
Medication Comparisons
Compare medications used to treat C1q Deficiency 3 C5830423. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy