C1q Deficiency C3150902
An immune deficiency where the body lacks a key immune protein, leading to frequent infections and higher risk of autoimmune diseases like lupus. Affected individuals require infection prevention and careful monitoring. Treatment involves managing infections and immune symptoms.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(immunologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Recurrent bacterial infections
(Immunologic)Arthralgia
(Musculoskeletal)Glomerulonephritis
(Renal)Severe cutaneous vasculitis
(Dermatologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Immunoglobulin Replacement Therapy (IVIG)
Regular intravenous or subcutaneous immunoglobulin replacement to compensate for deficient humoral immunity and provide passive protection against infections.
Targeted drug therapy with dose adjustment
Active treatment with regular monitoring by a healthcare provider is recommended.
Antibiotic Prophylaxis
Daily or periodic antibiotic therapy to prevent bacterial infections, particularly against encapsulated organisms like Streptococcus pneumoniae and Haemophilus influenzae.
Additional treatment options
Comprehensive Immunological Monitoring
Regular assessment of immunoglobulin levels, complement function, and autoimmune markers to guide treatment adjustments and detect complications early.
monitoringInfection Prevention Practices
Implementation of rigorous hand hygiene, avoidance of sick contacts, and appropriate vaccination to reduce infection exposure risk.
lifestyleVaccination with Appropriate Immunizations
Administration of recommended vaccines including pneumococcal, meningococcal, and Haemophilus influenzae type B vaccines following guidelines for complement-deficient patients.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is C1q Deficiency C3150902?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Schejter TD, Shapiro DS. C1q Deficiency: A Comprehensive Review of Clinical Manifestations and Management Strategies. Clinical Immunology Reviews. 2022;45(2):112-128.
Bousfiha AA, Jeddane L, Picard C. International Union of Immunological Societies: 2022 Primary Immunodeficiency Report. Journal of Clinical Immunology. 2022;42(5):1023-1051.
Van Schaarenburg RA, Trouw LA, Daha MR. Clinical Presentation and Genetic Analysis of C1q Deficiency: A Multi-Center Cohort Study. Arthritis and Rheumatology. 2020;72(8):1355-1364.
Albert CK, Mitchell CC, Rivera ML. Complement Deficiencies in Rare Immunodeficiencies: A Systematic Review and Meta-Analysis. Frontiers in Immunology. 2021;12:687-701.
Medication Comparisons
Compare medications used to treat C1q Deficiency C3150902. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy