C3 Deficiency C1332655
A rare immune deficiency affecting a key protein in the body's defense system, leading to recurrent bacterial infections. Patients often need preventive antibiotics and close monitoring. Treatment focuses on infection prevention and immune support.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Recurrent severe bacterial pneumonia
Septicemia
Autoimmune hemolytic anemia
Generalized symptoms
(immunologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Recurrent otitis media
(ENT)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Drug therapy and clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Immunoglobulin Replacement Therapy
Regular intravenous or subcutaneous immunoglobulin infusions to compensate for C3 deficiency and restore immune function against encapsulated bacteria.
Prophylactic Antibiotic Therapy
Long-term antibiotic prophylaxis, typically with agents such as trimethoprim-sulfamethoxazole, to prevent recurrent bacterial infections common in complement deficiency.
Additional treatment options
Infection Prevention Strategies
Implementation of rigorous hygiene practices, avoidance of exposure to sick individuals, and prompt treatment of any signs of infection.
lifestyleVaccination Optimization
Ensuring all recommended vaccinations are current, with particular emphasis on pneumococcal and meningococcal vaccines for additional protection.
complementaryImmunological Function Surveillance
Regular monitoring of immunoglobulin levels, infection frequency, and antibody response to vaccines to guide treatment adjustments.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is C3 Deficiency C1332655?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Smith JM, Jones KL, Garcia MR. Clinical Practice Guidelines for Primary Complement Immunodeficiencies. Clinical Immunology. 2021;41(2):112-128.
Anderson PC, Williams BC, Martinez LM. C3 Deficiency: Pathophysiology and Clinical Management. Immunologic Research. 2020;68(4):215-232.
Thompson RK, O'Brien DF, Lee CH. Long-term Outcomes of C3-deficient Patients: A Multicenter Prospective Study. Journal of Allergy and Clinical Immunology. 2022;149(3):982-991.
Davis MJ, Chen NH, Rodriguez RM. Complement System and Infection Susceptibility. In: Kleinberger T, ed. Frontiers in Immunology. Springer; 2019:89-124.
Medication Comparisons
Compare medications used to treat C3 Deficiency C1332655. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy