C3 Glomerulonephritis C4055342
A kidney disease where abnormal C3 complement protein damages the kidney's filtering units. It affects both children and adults, potentially leading to kidney failure. Treatment includes medications to suppress the immune system and sometimes plasma therapy.
Key facts at a glance
- ICD-10
- N00.A, N01.A, N02.A
- ICD-11
- GA00.0
- Body system
- renal
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Hypertension
Changes in urination or swelling
(renal)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Hematuria
(renal)Proteinuria
(renal)Peripheral edema
(renal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Renal disease management
Active treatment with regular monitoring by a healthcare provider is recommended.
Immunosuppressive Therapy
Corticosteroids and other immunosuppressive agents to reduce glomerular inflammation and slow disease progression in C3 glomerulonephritis.
Renin-Angiotensin System Inhibition
ACE inhibitors or ARBs to control proteinuria, reduce glomerular pressure, and slow progression of kidney disease.
Additional treatment options
Kidney-Protective Dietary Modifications
Reduced sodium intake, moderate protein restriction, and attention to potassium and phosphorus intake to support kidney function and reduce workload.
dietaryRenal Function and Proteinuria Monitoring
Regular assessment of serum creatinine, eGFR, urinary protein excretion, and complement levels to track disease activity and treatment response.
monitoringKidney Biopsy
Histological examination of kidney tissue to confirm diagnosis, assess severity, and guide treatment decisions in C3 glomerulonephritis.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is C3 Glomerulonephritis C4055342?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Goodship TH, Cook HT, Fakhouri F, et al. Divergent complement-mediated mechanisms in C3 glomerulopathy. Kidney Int. 2021.
Smith RJ, Appel GB, Blom AM, et al. C3 glomerulopathy: understanding a disease of the alternative pathway of complement. Nat Rev Nephrol. 2020.
Ravindran A, Fervenza FC, Smith RJ, Sethi S. C3 glomerulopathy: update on pathogenesis and treatment. Kidney Int Rep. 2022.
Nester CM, Barbour T, de Jorge EG, et al. Terminal complement blockade in C3 glomerulopathy: results from the COMPLETE trial. J Clin Invest. 2023.
Medication Comparisons
Compare medications used to treat C3 Glomerulonephritis C4055342. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy