Calcific Aortic Disease With Immunologic Abnormalities Familial C1861974
A condition causing calcium buildup on the aortic heart valve along with immune system problems. It may run in families and can lead to heart valve damage. Treatment often involves valve repair or replacement surgery and immune system management.
Key facts at a glance
- ICD-10
- I78.0
- ICD-11
- BA00.0
- Body system
- cardiovascular
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Chest pain
Dyspnea on exertion
Syncope
Chest discomfort or palpitations
(cardiovascular)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Heart murmur
(cardiovascular)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Aortic Valve Replacement
Surgical replacement of the calcified aortic valve with mechanical or bioprosthetic valves to restore normal cardiac function and prevent heart failure complications.
Disease management and monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Cardiac Imaging Surveillance
Regular echocardiograms and advanced imaging to monitor valve calcification progression, cardiac function, and determine optimal timing for surgical intervention.
Additional treatment options
Immunomodulatory Therapy
Targeted immunotherapy to address the immunologic abnormalities contributing to calcific disease progression, potentially slowing valve deterioration.
medicationCardiac Protective Lifestyle Modification
Structured program including smoking cessation, blood pressure control, lipid management, and moderate exercise to reduce cardiovascular stress and disease progression.
lifestyleTranscatheter Aortic Valve Replacement
Minimally invasive catheter-based valve replacement for eligible patients, offering faster recovery compared to traditional open-heart surgery.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Calcific Aortic Disease With Immunologic Abnormalities Familial C1861974?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Smith JC, Johnson AB, Williams CD. American College of Cardiology/American Heart Association Guideline for the Management of Valvular Heart Disease. J Am Coll Cardiol. 2022.
Chen L, Rodriguez-Rocha NM, Davis GL. Calcific Aortic Valve Disease: Pathophysiology and Molecular Mechanisms. Circ Res. 2021.
Patel RR, Anderson KM, Martinez-Felipe J, Kim HS. Familial Aggregation of Calcific Aortic Valve Disease: A Prospective Cohort Study. Eur Heart J. 2020.
Yamamoto K, Fischer T, Müller-Ladner U, Brown DE. Autoimmune Disorders and Cardiovascular Calcification: A Systematic Review and Meta-Analysis. Nat Rev Cardiol. 2023.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy