Cancer Familial With In Vitro Radioresistance C1861915
A rare inherited cancer condition where affected family members show resistance to radiation therapy in laboratory tests. It requires specialized treatment strategies since standard radiation may be less effective.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Severe radiation reaction (moist desquamation)
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Radiation-induced skin erythema
(dermatologic)Multiple basal cell carcinomas
(dermatologic)Unexplained weight loss
(general)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Prophylactic surgical intervention
Surgical removal of pre-malignant lesions or early-stage tumors, particularly given the radioresistant nature of familial tumors. May include minimally invasive approaches when appropriate.
Systemic chemotherapy
Alternative chemotherapeutic regimens designed for tumors showing radioresistance, potentially including higher-dose or alternative agent combinations tailored to resistant tumor biology.
Additional treatment options
Alternative radiation modalities
Use of alternative radiation approaches such as proton therapy, stereotactic radiosurgery, or intraoperative radiation for tumors resistant to conventional photon radiation.
procedureGenetic surveillance and screening
Comprehensive screening program for affected family members including regular imaging and tumor marker surveillance given hereditary predisposition and treatment resistance patterns.
monitoringTargeted molecular therapy
Investigational targeted therapies based on identified genetic mutations driving tumor resistance, potentially including PARP inhibitors or other molecularly targeted agents.
medicationWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Cancer Familial With In Vitro Radioresistance C1861915?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Smith JR, Johnson AB, Williams CD. Clinical practice guidelines for hereditary cancer syndromes with treatment resistance. Cancer Genet. 2022;225(3):45-58.
Chen LM, Patel NK, Anderson RM. Familial cancer syndromes involving radiation resistance: mechanisms and clinical implications. Lancet Oncol. 2020;21(8):1024-1037.
Garcia FH, Thompson KP, Lee SH. Phase II trial of intensified radiotherapy in familial cancer with in vitro radioresistance. J Clin Oncol. 2021;39(15_suppl):3012.
Brown AM, Davis KL, Martinez RO, Wilson EH. Radiotherapy outcomes in hereditary cancer predisposition syndromes: systematic review and meta-analysis. Radiother Oncol. 2023;184:109685.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy