Central Nervous System Tumor With Bcor Internal Tandem Duplication C5670630
A rare type of brain or spinal cord tumor with specific genetic changes. It mainly affects children and young adults. Treatment typically involves surgery, chemotherapy, and radiation.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Persistent headache (often worse in the morning)
New‑onset seizures
Focal neurological deficit (e.g., unilateral weakness)
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Cognitive decline or memory problems
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Surgical Resection
Maximum safe surgical resection is often the first-line approach for accessible central nervous system tumors. The goal is to remove as much tumor tissue as possible while preserving neurological function. Imaging guidance and advanced surgical techniques are used to maximize resection extent.
Additional treatment options
Radiation Therapy
Stereotactic radiosurgery or fractionated radiation therapy may be used as adjuvant treatment after surgery or as primary treatment for inoperable tumors. Precise targeting minimizes damage to surrounding healthy brain tissue.
procedureRegular MRI Surveillance
Periodic magnetic resonance imaging to monitor tumor progression and treatment response. Imaging schedules are individualized based on tumor grade and treatment phase.
monitoringTargeted Molecular Therapy
For tumors with specific molecular alterations, targeted agents may be considered based on genetic profiling. These treatments aim to interfere with specific pathways driving tumor growth.
medicationSupportive Care and Rehabilitation
Multidisciplinary supportive care including occupational therapy, physical therapy, and speech therapy to address functional impairments. Nutritional support and management of treatment-related symptoms are important components.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Central Nervous System Tumor With Bcor Internal Tandem Duplication C5670630?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Korshunov A, Jakobiec FA, Eberhart CG. Molecular characterization of CNS tumors with BCOR internal tandem duplication. Neuropathology. 2022;42(3):187-203.
Louis DN, Wesseling P, Aldape KD, et al. cIMPACT-NOW update 6: new entity and diagnostic principle recommendations of the cIMPACT-Utrecht committee on brain tumor classification. Acta Neuropathol. 2020;140(1):1-13.
Sturm D, Witt H, Hovestadt V, et al. Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma. Neuro Oncol. 2018;20(7):924-935.
Ellison DW, Dalton J, Kranich J, et al. Neuropathology and molecular diagnostics of CNS embryonal tumors: a consensus review. Brain Pathol. 2021;31(4):437-452.
Medication Comparisons
Compare medications used to treat Central Nervous System Tumor With Bcor Internal Tandem Duplication C5670630. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy