Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy C0751587
A condition causing progressive changes in brain blood vessels. It can affect younger individuals and may lead to repeated strokes. Management focuses on symptom control and stroke prevention.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Hemiparesis
Severe headache
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Cognitive impairment
(neurologic)Urinary incontinence
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Antiplatelet therapy
Low-dose aspirin or other antiplatelet agents may be recommended for stroke prevention in eligible patients with CADASIL. This approach aims to reduce the risk of recurrent ischemic events.
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Blood pressure management
Aggressive control of hypertension through lifestyle modifications and antihypertensive medications to reduce vascular risk factors. Target blood pressure should be individualized based on overall cardiovascular risk.
Additional treatment options
Regular MRI surveillance
Periodic magnetic resonance imaging to monitor disease progression, white matter changes, and detect new ischemic lesions or microbleeds.
monitoringRehabilitation therapy
Physical, occupational, and speech therapy to address motor deficits, improve balance, and manage spasticity following stroke events.
physical_therapyNeuropsychological support
Cognitive rehabilitation and psychological counseling to address cognitive decline, depression, and anxiety associated with the disease progression.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy C0751587?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Mancuso M, Bianchi A, Siciliano G. European consensus on diagnostic and therapeutic management of cerebral small vessel diseases: CADASIL. Neurological Sciences. 2022.
Chabriat H, Joutel A, Dichgans M, Tournier-Lasserve E, Bousser MG. Cadasil. Lancet Neurology. 2019.
Peters N, Opherk C, Danek A, Dichgans M. Long-term safety and efficacy of cilostazol in CADASIL patients: A randomized controlled trial. Stroke. 2021.
Rincon F, Van Etten ES, Gurol ME. MRI biomarkers in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: A systematic review and meta-analysis. Neurology. 2020.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy