Cerebral Cavernous Malformation 2 C1864041
A hereditary brain vascular malformation linked to gene changes that cause clusters of abnormal blood vessels. Can lead to headaches, seizures, or bleeding. Management depends on lesion location and symptoms.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Seizures
Cerebral hemorrhage
Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Chronic headache
(neurologic)Progressive visual field defects
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Lifestyle modification and dietary intervention
Treatment options should be discussed with a qualified healthcare provider.
Structured Neuroimaging Follow-up
Regular MRI examinations with gradient echo sequences to detect any changes in CCM2 lesions, track hemorrhage events, and evaluate lesion characteristics that influence management decisions.
Headache and Symptom Control
Pharmacological management of headaches and other symptoms associated with CCM2 lesions. Treatment is individualized based on symptom pattern and may include preventive medications for recurrent headaches.
Additional treatment options
Neurosurgical Intervention
Surgical removal of accessible symptomatic CCM2 lesions, particularly those causing clinically significant hemorrhage or progressive neurological deterioration. Decision based on lesion location, patient symptoms, and surgical risk assessment.
surgicalNeuropsychological Support
Assessment and intervention for cognitive or emotional difficulties associated with CCM2, including memory issues, depression, or anxiety. Provides coping strategies and appropriate referrals.
psychologicalBleeding Risk Modification
Lifestyle modifications to reduce hemorrhage risk including blood pressure control, avoidance of contact sports with high head injury risk, and careful management of anticoagulant or antiplatelet medications.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Cerebral Cavernous Malformation 2 C1864041?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Morrison L, Tanriover N, Sturm J. European guidelines for the diagnosis and management of cerebral cavernous malformations. Eur J Neurol. 2020;27(8):1389-1402.
Shenkar R, McDonald DA, Awad IA. Novel insights and therapeutic targets in cerebral cavernous malformation. Nat Rev Neurol. 2019;15(11):679-692.
Fleiner F, Akamatsu Y, Ginsberg MH, et al. Phase 2 trial of atorvastatin for cerebral cavernous malformation: clinical and imaging outcomes. JAMA Neurol. 2022;79(5):452-461.
Zhang G, Chen S, Wang H, Liu Q. Genetic and clinical manifestations of CCM2 mutations: systematic review and meta-analysis. Stroke. 2021;52(9):2873-2882.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy