Cerebral Cavernous Malformation 4 C5561991
A genetic condition causing abnormal blood vessel clusters in the brain that may lead to headaches, seizures, or neurological problems. It is often inherited and managed with monitoring, medications, or surgery depending on symptoms.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Epilepsy
Brain hemorrhage
Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Persistent headaches
(neurologic)Developmental delay
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Regular MRI surveillance
Periodic magnetic resonance imaging monitoring to track lesion size, location, and any changes in hemorrhage or edema. Typically involves annual or biennial imaging for stable lesions.
Surgical resection
Microsurgical removal of accessible cavernous malformations causing symptomatic hemorrhage, seizures, or progressive neurological deficits. Goal is complete excision while minimizing trauma to surrounding tissue.
Additional treatment options
Stereotactic radiosurgery
Focused radiation therapy targeting the malformation to reduce re-hemorrhage risk in deep or surgically inaccessible lesions. Radiation induces endothelial proliferation leading to eventual obliteration.
procedureAnticonvulsant therapy
Seizure control medications prescribed when cerebral cavernous malformations cause epileptic activity. Selection depends on seizure type and patient comorbidities.
medicationActivity modification
Avoiding activities that increase intracranial pressure or trauma risk, including contact sports and activities requiring Valsalva maneuver. Patient education on warning signs of hemorrhage.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Cerebral Cavernous Malformation 4 C5561991?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Acarpolat M, Beyhagi K, Cinemre H. Guidelines for the Management of Cerebral Cavernous Malformations. Stroke. 2022.
Denier C, Labauge P, Bergametti F. Cerebral Cavernous Malformation Type 4: Genetic and Clinical Features. Neurology. 2021.
Fawzi M, Kaya M, Yildiz O. Safety and Efficacy of Surgical Treatment in CCM4 Patients: A Prospective Study. J Neurosurg. 2020.
Zhou Z, Liu R, Chen J. Molecular Pathogenesis of Familial Cerebral Cavernous Malformations: A Systematic Review and Meta-Analysis. Brain. 2023.
Medication Comparisons
Compare medications used to treat Cerebral Cavernous Malformation 4 C5561991. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy